Dopamine Transporter Antibody (YA6549)
(Synonyms: DA transporter antibody; DAT 1 antibody; DAT antibody; DAT1 antibody; Dopamine transporter 1 antibody; Dopamine transporter antibody; PKDYS antibody; SC6A3_HUMAN antibody; SLC6A3 antibody; Sodium dependent dopamine transporter antibody; DA transporter antibody; DAT 1 antibody; DAT antibody; DAT1 antibody; Dopamine transporter 1 antibody; Dopamine transporter antibody; PKDYS antibody; SC6A3_HUMAN antibody; SLC6A3 antibody; Sodium dependent dopamine transporter antibody; Sodium-dependent dopamine transporter antibody; Solute carrier family 6 (neurotransmitter transporter dopamine), member 3 antibody; Solute carrier family 6 (neurotransmitter transporter), member 3 antibody; Solute carrier family 6 member 3 antibody; Variable number tandem repeat (VNTR) antibody; )Dopamine Transporter Antibody (YA6549) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Dopamine Transporter.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IHC-F, IHC-P
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Reactivity :
Mouse, Rat
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Formulation:
Supplied in PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-F
IHC-F: Immunohistochemistry-Frozen
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|---|---|
| Dilution Ratio | 1:2000 | 1:500-1:1000 | 1:500-1:1000 |
Product Details
Dopamine Transporter Antibody (YA6549) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Dopamine Transporter.
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Host Rabbit
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Clonality Recombinant,Monoclonal
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Species ReactivityMouse, Rat Predicted Reactivity: Human,Cynomolgus monkey,Pig
Note: The predicted reactivity is for reference only and should not be considered a guarantee of product performance.
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Observed Molecular WeightObserved band size: 75 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 69 kDa
Recombinant protein.
affinity purified.
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
Dopamine transporter (DAT) is a plasma membrane protein that mediates the reuptake of extracellular dopamine (DA) and controls the spatiotemporal dynamics of dopaminergic neurotransmission. DATs play a key role in terminating dopaminergic signalling and in maintaining a releasable pool of dopamine. DATs help to modulate the concentration of extraneuronal dopamine by actively shuttling released transmitter molecules back across the plasma membrane into dopaminergic neurons, where they can be sequestered for later reuse or enzymatic catabolism.
DAT is a principle target of various psychostimulant, nootropic, and antidepressant drugs, as well as certain drugs used recreationally, including the notoriously addictive stimulant cocaine. DAT ligands have traditionally been divided into two categories: cocaine-like inhibitors and amphetamine-like substrates. DAT is regulated by multiple signaling systems, such as PKC.
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Subcellular Localization
Cell membrane,Cell projection, neuron projection,Cell projection, axon
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Expression
Tissue_Specificity: Found in the substantia nigra and ventral tegmental dopamine neurons, in fibers of the medial forebrain bundle ascending into the striatum, and within dense fiber networks and varicosities in the dorsal and ventral striatum (at protein level) (PubMed:17296554, PubMed:19357284). Lower expression in the cortex (at protein level) (PubMed:19357284). Absent from the corpus callosum (PubMed:19357284). Expressed throughout the retina at postnatal day 8 (PubMed:30936473) -
Isoforms & Post-Translational Modification
Q61327: 619 amino acids, molecular weight 68805 Da.
Sumoylated on Lys-130 by PIAS2 or PIAS4; which is enhanced after ultraviolet irradiation and essential for cell-growth promoting activity and transforming activity丨Cys-106 is easily oxidized to sulfinic acid丨Undergoes cleavage of a C-terminal peptide and subsequent activation of protease activity in response to oxidative stress -
Subunit
Monomer (By similarity)
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SwissProt ID
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Synonyms
DA transporter antibody; DAT 1 antibody; DAT antibody; DAT1 antibody; Dopamine transporter 1 antibody; Dopamine transporter antibody; PKDYS antibody; SC6A3_HUMAN antibody; SLC6A3 antibody; Sodium dependent dopamine transporter antibody; DA transporter antibody; DAT 1 antibody; DAT antibody; DAT1 antibody; Dopamine transporter 1 antibody; Dopamine transporter antibody; PKDYS antibody; SC6A3_HUMAN antibody; SLC6A3 antibody; Sodium dependent dopamine transporter antibody; Sodium-dependent dopamine transporter antibody; Solute carrier family 6 (neurotransmitter transporter dopamine), member 3 antibody; Solute carrier family 6 (neurotransmitter transporter), member 3 antibody; Solute carrier family 6 member 3 antibody; Variable number tandem repeat (VNTR) antibody;
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