Slc6a3 - solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 Gene

Also Known as DAT; Dat1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 13162

About Slc6a3

Chromosome 13: 73,684,866-73,726,791 forward strand.GRCm39:CM001006.3

This gene has 1 transcript (splice variant), 166 orthologues, 20 paralogues and is associated with 62 phenotypes. Low expression observed in reference dataset.

Summary

Enables several functions, including dopamine binding activity; dopamine:sodium symporter activity; and protein N-terminus binding activity. Involved in dopamine uptake; hyaloid vascular plexus regression; and neurotransmitter uptake. Acts upstream of or within several processes, including dopamine metabolic process; gland development; and prepulse inhibition. Located in axon and cell surface. Is expressed in genitourinary system; nervous system; spleen; and submandibular gland. Used to study Gilles de la Tourette syndrome; attention deficit hyperactivity disorder; and schizophrenia. Human ortholog(s) of this gene implicated in attention deficit hyperactivity disorder; nicotine dependence; and obesity. Orthologous to human SLC6A3 (solute carrier family 6 member 3). [provided by Alliance of Genome Resources, Apr 2022]

Slc6a3 Products (1)

mRNA Protein Name
NM_010020.3 NP_034150.1 sodium-dependent dopamine transporter

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables dopamine binding IDA
IDA: Inferred from direct assay
18671743 MGI
enables dopamine:sodium symporter activity IDA
IDA: Inferred from direct assay
10375632 MGI
enables dopamine:sodium symporter activity IMP
IMP: Inferred from mutant phenotype
9520487 MGI
enables monoamine transmembrane transporter activity IMP
IMP: Inferred from mutant phenotype
20858707 MGI
enables neurotransmitter transmembrane transporter activity IMP
IMP: Inferred from mutant phenotype
20858707 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
17296554 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within adenohypophysis development IMP
IMP: Inferred from mutant phenotype
9247269 MGI
acts upstream of or within cognition IMP
IMP: Inferred from mutant phenotype
28855580 MGI
acts upstream of or within dopamine biosynthetic process IMP
IMP: Inferred from mutant phenotype
9520487 MGI
acts upstream of or within dopamine catabolic process IMP
IMP: Inferred from mutant phenotype
9520487 MGI
acts upstream of or within dopamine transport IMP
IMP: Inferred from mutant phenotype
9520487 MGI
involved in dopamine uptake IMP
IMP: Inferred from mutant phenotype
20858707 MGI
involved in hyaloid vascular plexus regression IDA
IDA: Inferred from direct assay
30936473 MGI
acts upstream of or within lactation IMP
IMP: Inferred from mutant phenotype
9247269 MGI
acts upstream of or within locomotory behavior IGI
IGI: Inferred from genetic interaction
11150348 MGI
acts upstream of or within locomotory behavior IMP
IMP: Inferred from mutant phenotype
11150348 MGI
involved in neurotransmitter transport IMP
IMP: Inferred from mutant phenotype
20858707 MGI
involved in neurotransmitter uptake IDA
IDA: Inferred from direct assay
8628395 MGI
involved in neurotransmitter uptake IMP
IMP: Inferred from mutant phenotype
8628395 MGI
acts upstream of or within positive regulation of multicellular organism growth IMP
IMP: Inferred from mutant phenotype
9247269 MGI
acts upstream of or within prepulse inhibition IMP
IMP: Inferred from mutant phenotype
11150348 MGI
acts upstream of or within regulation of dopamine metabolic process IMP
IMP: Inferred from mutant phenotype
9247269 MGI
acts upstream of or within response to cocaine IDA
IDA: Inferred from direct assay
18671743 MGI
acts upstream of or within sensory perception of smell IMP
IMP: Inferred from mutant phenotype
16765459 MGI
Cellular Component GO Annotation Evidence References Source
located in axon IDA
IDA: Inferred from direct assay
17761882 MGI
located in axon terminus IDA
IDA: Inferred from direct assay
17296554 MGI
located in cell surface IDA
IDA: Inferred from direct assay
21399631 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Slc6a3 Protein Structure

SLC5-6-like_sbd

SLC5-6-like_sbd: cl00456 (59 - 612)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 619 a.a.
Protein Preferred Names Protein Names

sodium-dependent dopamine transporter

  • DA transporter

  • dopamine transporter 1

Slc6a3 Antibodies

Cat. No. Product Name Application Reactivity
HY-P86855 Dopamine Transporter Antibody (YA6548) IHC-F, IHC-P, WB Mouse, Rat
HY-P86856 Dopamine Transporter Antibody (YA6549) WB, IHC-F, IHC-P Mouse, Rat

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13308 SLC6A3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS13309 Slc6a3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS13310 Slc6a3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Slc6a3 NCBI NCBI:6531