Dynactin Subunit 3 Antibody (YA2762)
(Synonyms: DCNT22; DCTN22; Dctn3; dynactin 3 (p22); dynactin light chain; Dynactin subunit 3; p22)Dynactin Subunit 3 Antibody (YA2762) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Dynactin Subunit 3.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IHC-P, ICC/IF
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
|---|---|---|---|
| Dilution Ratio | 1:500-1:1000 | 1:50-1:100 | 1:50-1:200 |
Product Details
Dynactin Subunit 3 Antibody (YA2762) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Dynactin Subunit 3.
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Host Rabbit
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Clonality Recombinant,Monoclonal
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Species ReactivityHuman, Mouse, Rat
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Observed Molecular WeightObserved band size: 21 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 21 kDa
Entrez Gene: 11258 Human ; 53598 Mouse ; 362504 Rat
SwissProt: O75935 Human ; Q9Z0Y1 Mouse ;
OMIM: 607387 Human
A synthesized peptide derived from human DCTN3 aa100-186/186.
Endogenous
Affinity Purified
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
Dynactin Subunit 3 is a Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules. Together with dynein may be involved in spindle assembly and cytokinesis[1].
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Subcellular Localization
Cytoplasm; Cytoplasm, cytoskeleton, microtubule organizing center, centrosome; Chromosome, centromere, kinetochore; Cytoplasm, cytoskeleton, spindle; Cleavage furrow; Midbody
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Expression
Tissue_specificity:Ubiquitously expressed. Highly expressed in muscle and pancreas and detected at lower levels in brain -
Isoforms & Post-Translational Modification
O75935 has 3 isomers: O75935-1: 21119 Da (predicted); O75935-2: 19469 Da (predicted); O75935-3: 18001 Da (predicted).
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Subunit
Subunit of dynactin, a multiprotein complex part of a tripartite complex with dynein and a adapter, such as BICDL1, BICD2 or HOOK3. The dynactin complex is built around ACTR1A/ACTB filament and consists of an actin-related filament composed of a shoulder domain, a pointed end and a barbed end. Its length is defined by its flexible shoulder domain. The soulder is composed of 2 DCTN1 subunits, 4 DCTN2 and 2 DCTN3. The 4 DCNT2 (via N-terminus) bind the ACTR1A filament and act as molecular rulers to determine the length. The pointed end is important for binding dynein-dynactin cargo adapters. Consists of 4 subunits: ACTR10, DCNT4, DCTN5 and DCTN6. The barbed end is composed of a CAPZA1:CAPZB heterodimers, which binds ACTR1A/ACTB filament and dynactin and stabilizes dynactin
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SwissProt ID
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Synonyms
DCNT22; DCTN22; Dctn3; dynactin 3 (p22); dynactin light chain; Dynactin subunit 3; p22
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Research Field
Cell Biology
Documentation
References
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