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Cat. No.: HY-P89938

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EpoR Antibody (YA9282)

Name: EpoR Antibody (YA9282)
Brand: MedChemExpress
SKU: HY-P89938
Price: 125.00 USD
Availability: InStock
Rating: 5 (1 reviews)

(Synonyms: Erythropoietin receptor, EPO-R, EPOR)

Customer Review

Based on 1 Customer Validation

EpoR Antibody (YA9282) is a Mouse-derived and non-conjugated IgG3 monoclonal antibody, targeting to EpoR.

For research use only. We do not sell to patients.

Host:
Mouse
Isotype:
IgG
Application:
ICC/IF, IF-Tissue, IP, ELISA
Reactivity :
human

Formulation:
Supplied in PBS(pH7.4) containing 0.1% gelatin and < 0.1% sodium azide.

Conjugation:
Non-conjugated

Size

Price

Stock

Quantity

Amount: USD 0.00

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Applications
Product Details
Product Properties
- Appearance
- Formulation
- Concentration
- Storage & Stability
- Shipping
Background
Documentation
References
Help & FAQs
Classifications
Bioz

Applications

Application	ICC/IF ICC/IF: Immunocytochemistry/ Immunofluorescence	IF-Tissue IF-Tissue: Immunofluorescence-Tissue	IP IP: Immunoprecipitation	ELISA ELISA: Enzyme Linked Immunosorbent Assay
Dilution Ratio	1:50-500	1:50-500	1-2μg per 100-500μg Total protein	1:50-3000

Product Details

Description

EpoR Antibody (YA9282) is a Mouse-derived and non-conjugated IgG3 monoclonal antibody, targeting to EpoR.

Host Mouse
Species Reactivity
human
Calculated Molecular Weight Predicted band size: 55 kDa

Species Reactivity Database

OMIM: 133171

Immunogen

A synthesized peptide derived from human EpoR.

Sensitivity

Endogenous

Purification

Affinity purified

Conjugation

Non-conjugated

Modification

Unmodified

Isotype

IgG

Product Properties

Appearance

Solution
Formulation

Supplied in PBS(pH7.4) containing 0.1% gelatin and < 0.1% sodium azide.
Concentration

Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration
Storage & Stability

Stored at 2-8°C for 1 year, do not freeze.
Shipping

Shipping with blue ice.

Background

Function

EpoR is a Receptor for erythropoietin, which mediates erythropoietin-induced erythroblast proliferation and differentiation. Upon EPO stimulation, EPOR dimerizes triggering the JAK2/STAT5 signaling cascade (By similarity). In some cell types, can also activate STAT1 and STAT3. May also activate the LYN tyrosine kinase (By similarity)^[1]^[2]^[3]^[4]^[5]^[6].
Subcellular Localization

Cell membrane
Expression

Tissue_Specificity: Erythroid cells and erythroid progenitor cells.
Isoforms & Post-Translational Modification

EpoR has 3 isoforms, P19235-1: amino acid length is 508, molecular weight is 55065 Da (predicted); P19235-2: amino acid length is 241, molecular weight is 26456 Da (predicted); P19235-3: amino acid length is 328, molecular weight is 35809 Da (predicted).
On EPO stimulation, phosphorylated on C-terminal tyrosine residues by JAK2. The phosphotyrosine motifs are also recruitment sites for several SH2-containing proteins and adapter proteins which mediate cell proliferation. Tyr-426 is also required for SOCS3 binding, but Tyr-454/Tyr-456 motif is the preferred binding site
Subunit

Forms homodimers on EPO stimulation.
SwissProt ID

P19235
Gene ID

2057 [NCBI]
Synonyms

Erythropoietin receptor, EPO-R, EPOR

Documentation

Select Batch:

Data Sheet (260 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
User Guide for Antibodies (1077 KB)

References

[1]. Zhan H, et al. Engineering a soluble extracellular erythropoietin receptor (EPObp) in Pichia pastoris to eliminate microheterogeneity, and its complex with erythropoietin. Protein Eng. 1999 Jun;12(6):505-13. [Content Brief]

[2]. Winkelmann JC, et al. The gene for the human erythropoietin receptor: analysis of the coding sequence and assignment to chromosome 19p. Blood. 1990 Jul 1;76(1):24-30. [Content Brief]

[3]. Jones SS, et al. Human erythropoietin receptor: cloning, expression, and biologic characterization. Blood. 1990 Jul 1;76(1):31-5. [Content Brief]

[4]. Middleton SA, et al. Identification of a critical ligand binding determinant of the human erythropoietin receptor. Evidence for common ligand binding motifs in the cytokine receptor family. J Biol Chem. 1996 Jun 14;271(24):14045-54. [Content Brief]

[5]. Syed RS, et al. Efficiency of signalling through cytokine receptors depends critically on receptor orientation. Nature. 1998 Oct 1;395(6701):511-6. [Content Brief]

[6]. Kirito K, et al. Identification of the human erythropoietin receptor region required for Stat1 and Stat3 activation. Blood. 2002 Jan 1;99(1):102-10. [Content Brief]