ERCC1 Antibody (YA5357)
(Synonyms: ERCC1; DNA excision repair protein ERCC-1)ERCC1 Antibody (YA5357) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to ERCC1.
-
Host:
Mouse
-
Application:
WB, IHC-P, ICC/IF,
-
Reactivity :
Human
-
Formulation:
Supplied in PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol.
-
Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
|
WB
WB: Western Blot
|
ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
|---|---|---|---|
| Dilution Ratio | 100-300 | 1:1000 | 1:50-200 |
Product Details
ERCC1 Antibody (YA5357) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to ERCC1.
-
Host Mouse
-
Clonality Monoclonal
-
Species ReactivityHuman
-
Observed Molecular WeightObserved band size: 36 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
Synthetic Peptide of ERCC1
affinity chromatography.
Non-conjugated
Unmodified
Product Properties
-
Appearance
Liquid
-
Formulation
Supplied in PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol.
-
Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
-
Shipping
Shipping with blue ice.
Background
-
Function
ERCC1 is a Non-catalytic component of a structure-specific DNA repair endonuclease responsible for the 5'-incision during DNA repair. Responsible, in conjunction with SLX4, for the first step in the repair of interstrand cross-links (ICL). Participates in the processing of anaphase bridge-generating DNA structures, which consist in incompletely processed DNA lesions arising during S or G2 phase, and can result in cytokinesis failure. Also required for homology-directed repair (HDR) of DNA double-strand breaks, in conjunction with SLX4; Not functional in the nucleotide excision repair pathway; Not functional in the nucleotide excision repair pathway; Not functional in the nucleotide excision repair pathway
-
Subcellular Localization
Nucleus; Cytoplasm; Nucleus; Nucleus; Nucleus
-
Isoforms & Post-Translational Modification
P07992 has 4 isomers: P07992-1: 32562 Da (predicted); P07992-2: 29993 Da (predicted); P07992-3: 35563 Da (predicted); P07992-4: 25211 Da (predicted).
Ubiquitinated with both 'Lys-48' and 'Lys-63' linkages (PubMed:25538220). Deubiquitinated by USP45 (PubMed:25538220) -
Subunit
Heterodimer composed of ERCC1 isoform 1 and ERCC4/XPF (PubMed:16076955, PubMed:16338413, PubMed:24036546, PubMed:25538220, PubMed:32034146). Interacts with USP45 (PubMed:25538220)
-
SwissProt ID
-
Synonyms
ERCC1; DNA excision repair protein ERCC-1
Documentation
Powered by Bioz
