FA2H Antibody (YA8628)
(Synonyms: FAAH; FAH1; FAXDC1; SCS7; SPG35)FA2H Antibody (YA8628) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to FA2H.
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Host:
Mouse
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Isotype:
IgG1
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Application:
ICC/IF
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Reactivity :
Human
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Formulation:
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Conjugation:
Non-conjugated
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Applications
| Application |
ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
|---|---|
| Dilution Ratio | 1:50-1:100 |
Product Details
FA2H Antibody (YA8628) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to FA2H.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman
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Calculated Molecular Weight Predicted band size: 42.6 kDa
Full length human recombinant protein of human FA2H produced in HEK293T cell.
Endogenous
Affinity purified
Non-conjugated
Unmodified
IgG1
Product Properties
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Appearance
Liquid
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Formulation
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
FA2H catalyzes the hydroxylation of free fatty acids at the C-2 position to produce 2-hydroxy fatty acids, which are building blocks of sphingolipids and glycosphingolipids common in neural tissue and epidermis. FA2H is stereospecific for the production of (R)-2-hydroxy fatty acids. Plays an essential role in the synthesis of galactosphingolipids of the myelin sheath. Responsible for the synthesis of sphingolipids and glycosphingolipids involved in the formation of epidermal lamellar bodies critical for skin permeability barrier. Participates in the synthesis of glycosphingolipids and a fraction of type II wax diesters in sebaceous gland, specifically regulating hair follicle homeostasis. Involved in the synthesis of sphingolipids of plasma membrane rafts, controlling lipid raft mobility and trafficking of raft-associated proteins[1][2][3][4].
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Subcellular Localization
Endoplasmic reticulum membrane,Microsome membrane
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Expression
Tissue_Specificity: Detected in differentiating cultured keratinocytes (at protein level). Detected in epidermis and cultured keratinocytes (PubMed:17355976). Highly expressed in brain and colon. Detected at lower levels in testis, prostate, pancreas and kidney (PubMed:15337768)
Induction: Up-regulated during keratinocyte differentiation -
Isoforms & Post-Translational Modification
Q7L5A8 has two isomers: Q7L5A8-1: 42791 Da (predicted); Q7L5A8-2: 18324 Da (predicted).
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SwissProt ID
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Synonyms
FAAH; FAH1; FAXDC1; SCS7; SPG35
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