FADS1 Antibody (YA2910)(PBS only)

Cat. No.: HY-P83165A: Data Sheet User Guide for Antibodies
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FADS1 Antibody (YA2910) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to FADS1.

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사이즈		재고
50 μL		견적 받기
100 μL		견적 받기

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
제품 설명

제품 설명

FADS1 Antibody (YA2910) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to FADS1.

Host

Rabbit

분자량

Predicted band size: 52 kDa;

Observed band size: 52 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.

Species Reactivity

Human, Mouse, Rat

SwissProt ID

O60427

Gene ID

3992 [NCBI]

Immunogen

A synthetic peptide of human FADS1 aa101-114.

Application &
Dilution Ratio

Application	Dilution Ratio
WB WB: Western Blot	1:500-1:1000
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:50-1:100
IHC-F IHC-F: Immunohistochemistry-Frozen	1:50-1:100
ICC/IF ICC/IF: Immunocytochemistry/Immunofluorescence	1:50-1:200

Purity	Affinity Purified	Conjugation	Non-conjugated
Isotype	IgG

Appearance

Liquid

Formulation

Supplied in PBS, pH 7.4.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

선적

Shipping with blue ice.

Background

Function：Acts as a front-end fatty acyl-coenzyme A (CoA) desaturase that introduces a cis double bond at carbon 5 located between a preexisting double bond and the carboxyl end of the fatty acyl chain. Involved in biosynthesis of highly unsaturated fatty acids (HUFA) from the essential polyunsaturated fatty acids (PUFA) linoleic acid (LA) (18:2n-6) and alpha-linolenic acid (ALA) (18:3n-3) precursors. Specifically, desaturates dihomo-gamma-linoleoate (DGLA) (20:3n-6) and eicosatetraenoate (ETA) (20:4n-3) to generate arachidonate (AA) (20:4n-6) and eicosapentaenoate (EPA) (20:5n-3), respectively (PubMed:10601301, PubMed:10769175). As a rate limiting enzyme for DGLA (20:3n-6) and AA (20:4n-6)-derived eicosanoid biosynthesis, controls the metabolism of inflammatory lipids like prostaglandin E2, critical for efficient acute inflammatory response and maintenance of epithelium homeostasis. Contributes to membrane phospholipid biosynthesis by providing AA (20:4n-6) as a major acyl chain esterified into phospholipids. In particular, regulates phosphatidylinositol-4,5-bisphosphate levels, modulating inflammatory cytokine production in T-cells (By similarity). Also desaturates (11E)-octadecenoate (trans-vaccenoate)(18:1n-9), a metabolite in the biohydrogenation pathway of LA (18:2n-6) (By similarity); Does not exhibit any catalytic activity toward 20:3n-6, but it may enhance FADS2 activity

Subcellular Localization：Endoplasmic reticulum membrane; Multi-pass membrane protein; Mitochondrion; Endoplasmic reticulum membrane; Multi-pass membrane protein

Expression：
Tissue_specificity:Widely expressed, with highest levels in liver, brain, adrenal gland and heart. Highly expressed in fetal liver and brain

Induction:Strongly down-regulated upon differentiation in a neuroblastoma cell line (at protein level)

Isoforms & Post-Translational Modification：O60427 has 2 isomers: O60427-1: 51964 Da (predicted); O60427-2: 42474 Da (predicted).

Research Field

Tags & Cell Markers

Synonyms

D5D; TU12; FADS6; FADSD5; LLCDL1

각종 서류

User Guide for Antibodies (1077 KB)