Fibulin 1 Antibody (YA2831)(PBS only)

Cat. No.: HY-P83086A: Data Sheet User Guide for Antibodies
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Fibulin 1 Antibody (YA2831) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Fibulin 1.

For research use only. We do not sell to patients.

Size		Stock
50 μL		Get quote
100 μL		Get quote

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Documentation

Description

Fibulin 1 Antibody (YA2831) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Fibulin 1.

Host

Rabbit

Molecular Weight

Predicted band size: 77 kDa;

Observed band size: 77 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.

Species Reactivity

Human, Mouse

SwissProt ID

P23142

Gene ID

2192 [NCBI]

Immunogen

Recombinant protein of human Fibulin 1 266—402.

Application &
Dilution Ratio

Application	Dilution Ratio
WB WB: Western Blot	1:500-1:1000
IP IP: Immunoprecipitation	1:20

Purity	Affinity Purified	Conjugation	Non-conjugated
Isotype	IgG

Appearance

Liquid

Formulation

Supplied in PBS, pH 7.4.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Background

Function：Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes. Has been implicated in a role in cellular transformation and tumor invasion, it appears to be a tumor suppressor. May play a role in haemostasis and thrombosis owing to its ability to bind fibrinogen and incorporate into clots. Could play a significant role in modulating the neurotrophic activities of APP, particularly soluble APP

Subcellular Localization：Secreted, extracellular space, extracellular matrix

Expression：
Tissue_specificity:Isoform A and isoform B are only expressed in placenta. Isoform C and isoform D are expressed in a variety of tissues and cultured cells

Induction:Expression increased by estrogen in ovarian cancer cells

Isoforms & Post-Translational Modification：P23142 has 4 isomers: P23142-1: 77214 Da (predicted); P23142-2: 61552 Da (predicted); P23142-3: 65443 Da (predicted); P23142-4: 74434 Da (predicted).

Subunit：Homomultimerizes and interacts with various extracellular matrix components such as FN1, LAMA1, LAMA2, NID, ACAN, CSPG2 and type IV collagen. Also interacts with APP and FGB. Interacts with FBLN7 (By similarity). Interacts with CCN3 (PubMed:9927660)

Research Field

Cardiovascular

Synonyms

FBLN; FIBL1

Documentation

User Guide for Antibodies (1077 KB)