GFRA1 Antibody
(Synonyms: GDNFRA, RETL1, TRNR1, GFRA1, GDNF family receptor alpha-1, GDNF receptor alpha-1, GDNFR-alpha-1, GFR-alpha-1, RET ligand 1, TGF-beta-related neurotrophic factor receptor 1)GFRA1 Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to GFRA1.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IHC-P, ICC/IF
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in PBS (pH 7.4), containing 30% glycerol, and 0.01% sodium azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
|---|---|---|---|
| Dilution Ratio | 1:1000-2000 | 1:100-200 | 1:50-200 |
Product Details
GFRA1 Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to GFRA1.
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Host Rabbit
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Clonality Polyclonal
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Species ReactivityHuman, Mouse, Rat
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Observed Molecular WeightObserved band size: 55 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 50; 51 kDa
Purified recombinant protein of human GFRA1
Endogenous
affinity purified.
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS (pH 7.4), containing 30% glycerol, and 0.01% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
GFRA1 is a Coreceptor for GDNF, a neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake. GDNF-binding leads to autophosphorylation and activation of the RET receptor[1][2].
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Subcellular Localization
Cell membrane; Golgi apparatus, trans-Golgi network; Endosome; Endosome, multivesicular body
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Isoforms & Post-Translational Modification
GFRA1 has 2 isoforms, P56159-1: amino acid length is 465, molecular weight is 51456 Da (predicted); P56159-2: amino acid length is 460, molecular weight is 50838 Da (predicted).
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Subunit
Interacts with GDNF ligand and RET: forms a 2:2:2 ternary complex composed of GDNF ligand, GFRA1 and RET receptor.
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SwissProt ID
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Synonyms
GDNFRA, RETL1, TRNR1, GFRA1, GDNF family receptor alpha-1, GDNF receptor alpha-1, GDNFR-alpha-1, GFR-alpha-1, RET ligand 1, TGF-beta-related neurotrophic factor receptor 1
Documentation
[1]. Cik M, et al. Binding of GDNF and neurturin to human GDNF family receptor alpha 1 and 2. Influence of cRET and cooperative interactions. J Biol Chem. 2000 Sep 8;275(36):27505-12. [Content Brief]
[2]. Li J, et al. Cryo-EM analyses reveal the common mechanism and diversification in the activation of RET by different ligands. Elife. 2019 Sep 19;8:. [Content Brief]
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