HBsAg Antibody (YA913)(PBS only)
(Synonyms: L glycoprotein; L-HBsAg; LHB; Large S protein; Large surface protein; Major surface antigen; S; HBSAG_HBVC5. )HBsAg Antibody (YA913) is a Mouse-derived and non-conjugated IgM monoclonal antibody, targeting to HBsAg.
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Host:
Mouse
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Isotype:
IgM
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Application:
ELISA
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Formulation:
Supplied in PBS, pH 7.4.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
ELISA
ELISA: Enzyme Linked Immunosorbent Assay
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|---|---|
| Dilution Ratio | 1:10000 |
Product Details
HBsAg Antibody (YA913) is a Mouse-derived and non-conjugated IgM monoclonal antibody, targeting to HBsAg.
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Host Mouse
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Calculated Molecular Weight Predicted band size: 44 kDa
HBsAg antibody was raised in mouse using highly purified hepatitis B surface antigen as the immunogen.
affinity purified
Non-conjugated
IgM
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS, pH 7.4.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
HBsAg is a The large envelope protein exists in two topological conformations, one which is termed 'external' or Le-HBsAg and the other 'internal' or Li-HBsAg. In its external conformation the protein attaches the virus to cell receptors and thereby initiating infection. This interaction determines the species specificity and liver tropism. This attachment induces virion internalization predominantly through caveolin-mediated endocytosis. The large envelope protein also assures fusion between virion membrane and endosomal membrane. In its internal conformation the protein plays a role in virion morphogenesis and mediates the contact with the nucleocapsid like a matrix protein; The middle envelope protein plays an important role in the budding of the virion. It is involved in the induction of budding in a nucleocapsid independent way. In this process the majority of envelope proteins bud to form subviral lipoprotein particles of 22 nm of diameter that do not contain a nucleocapsid
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Subcellular Localization
Virion membrane
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Isoforms & Post-Translational Modification
P03141 has 3 isomers: P03141-1: 43705 Da (predicted); P03141-2: 31141 Da (predicted); P03141-3: 25394 Da (predicted).
Isoform M is N-terminally acetylated by host at a ratio of 90%, and N-glycosylated by host at the pre-S2 region;Myristoylated -
Subunit
In its internal form (Li-HBsAg), interacts with the capsid protein and with the isoform S (PubMed:31700077). Interacts with host chaperone CANX (PubMed:9188622)
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SwissProt ID
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Synonyms
L glycoprotein; L-HBsAg; LHB; Large S protein; Large surface protein; Major surface antigen; S; HBSAG_HBVC5.
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