2. Antibodies
  3. Primary Antibodies
  4. Monoclonal Antibodies
  5. Human IgG1 Antibody (YA7187)

Human IgG1 Antibody (YA7187)

製品番号: HY-P87502
User Guide for Antibodies Technical Support

Human IgG1 is a non-conjugated and rabbit origined monoclonal antibody, targeting to Human IgG1. It can be used as an isotype control.

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容量 在庫状況
50 μL   お問い合わせ  
100 μL   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

Top Publications Citing Use of Products
  • WB: Western Blot;
  • IHC-P: Immunohistochemistry-Paraffin;
  • IHC-F: Immunohistochemistry-Frozen;
  • ICC/IF: Immunocytochemistry/Immunofluorescence;
  • IF-Tissue: Immunofluorescence-Tissue;
  • mIHC: Multiplex Immunohistochemical;
  • IP: Immunoprecipitation;
  • ChIP: Chromatin Immunoprecipitation;
  • FC: Flow Cytometry;
  • ELISA: Enzyme Linked Immunosorbent Assay

  • Product Detail

  • Background

  • 説明

製品説明

Human IgG1 is a non-conjugated and rabbit origined monoclonal antibody, targeting to Human IgG1. It can be used as an isotype control.
Host

Rabbit
Clonality

Monoclonal,Recombinant
分子量
Predicted band size: 44 kDa;
Observed band size: 52 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
Species Reactivity
Human
SwissProt ID
Gene ID
Immunogen

A synthesized peptide derived from human Human IgG1 : 90-120
Application &
Dilution Ratio
Application Dilution Ratio
WB
WB: Western Blot
1:1000-2000
純度 affinity purified Conjugation Non-conjugated
Modification Unmodified Isotype IgG
Appearance

Liquid
Formulation

Supplied in 10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
輸送条件

Shipping with blue ice.
Background
Function：Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414).
Subcellular Localization：Isoform 1 Secreted; Isoform 2 Cell membrane
Isoforms & Post-Translational Modification：Human (P01857) has 2 isomers: P01857-1: 36,106 Da (predicted); P01857-2: 43,912 Da (predicted).
Human (P01859) has two isomers: P01859-1: 35,901 Da (predicted); P01859-2: 43,806 Da (predicted).
Human (P01860) has two isomers: P01860-1: 41,287 Da (predicted); P01860-2: 49,093 Da (predicted).
Human (P01861) has two isomers: P01861-1: 35,941 Da (predicted); P01861-2: 43,832 Da (predicted).
P01857: Glycosylation on Asn-180 is required for interaction with Fc receptors and ability to activate the complement pathway.
P01859: Glycosylation on Asn-176 is required for interaction with Fc receptors and ability to activate the complement pathway.
P01860: N-linked glycans at Asn-322 are noncore fucosylated and the vast majority are diantennary species with a bisecting GlcNAc.
P01861: Glycosylation on Asn-177 is required for interaction with Fc receptors and ability to activate the complement pathway.
Subunit：P01857: Immunoglobulins are composed of two identical heavy chains and two identical light chains; disulfide-linked (PubMed:20176268). Interacts with FCGR1A; this interaction mediates IgG effector functions on monocytes. Interacts with FCGR2A and FCGR3A (PubMed:11711607).
P01859, P01860 and P01861: Immunoglobulins are composed of two identical heavy chains and two identical light chains; disulfide-linked.
ドキュメンテーション
User Guide for Antibodies (1077 KB)

Human IgG1 Antibody (YA7187) 関連分類

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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製品名:
Human IgG1 Antibody (YA7187)
製品番号:
HY-P87502
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