IGHG1 - immunoglobulin heavy constant gamma 1 (G1m marker) Gene

Species: Homo sapiens

Gene Type: other

Gene ID: 3500

About IGHG1

Cytogenetic location: 14q32.33 Genomic coordinates (GRCh38): 14:105,741,473-105,743,070 (from NCBI)

This gene has 3 transcripts (splice variants), 1 gene allele, 119 orthologues, 82 paralogues and is associated with 2 phenotypes.

Summary

Predicted to enable antigen binding activity and immunoglobulin receptor binding activity. Predicted to be involved in several processes, including activation of immune response; defense response to Other organism; and phagocytosis. Predicted to act upstream of or within several processes, including immunoglobulin mediated immune response; positive regulation of hypersensitivity; and positive regulation of phagocytosis. Located in extracellular space. [provided by Alliance of Genome Resources, Apr 2022]

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables Fc-gamma receptor I complex binding	IDA IDA: Inferred from direct assay	11711607	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11567028	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in adaptive immune response	IDA IDA: Inferred from direct assay	11498595	GOA
involved in antibody-dependent cellular cytotoxicity	IDA IDA: Inferred from direct assay	11711607	GOA
involved in complement-dependent cytotoxicity	IDA IDA: Inferred from direct assay	11711607	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of IgG immunoglobulin complex	IPI IPI: Inferred from physical interaction	9530559	GOA
located in extracellular space	IDA IDA: Inferred from direct assay	25645918	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IGHG1 Protein Structure

C1-set

0
100
200
300
330 a.a.

IGHG1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	IGHG1	P01857	FCGR2B	Homo sapiens	P31994	SPR	11567028
Intra	IGHG1	P01857	FCGR2B	Homo sapiens	P31994	ITC	11567028

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant IGHG1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72379	IgG1 Protein, Human (Biotinylated, HEK293, Avi)	P01857-1 (D104-K330, D239E, L241M)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P73143	IgG1 Protein, Human (C103S, HEK293)	P01857-1 (E99-K330, C103S)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P73903	IgG1 Protein, Human (CHO, C103S)	P01857-1 (E99-K330, C103S)	≥ 90%, as determined by reducing SDS-PAGE.
HY-P77526	IgG1 Protein, Human (Biotinylated, C103S, HEK293)	P01857-1 (E99-K330, C103S)	≥ 90%, as determined by reducing SDS-PAGE.

IGHG1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P810765	Human IgG1 Antibody (YA10008)	WB, ICC/IF	Human, Mouse, Rat
HY-P810892	Human IgG1 Antibody	WB, IHC-P	Human
HY-P87502	Human IgG1 Antibody (YA7187)	WB	Human

Related Diseases

Diseases	Alias
Leukemia, Chronic Lymphocytic	Chronic Lymphocytic Leukemia B-Cell Chronic Lymphocytic Leukemia CLL B-Cell Chronic Lymphoid Leukemia Chronic Lymphatic Leukemia Chronic Lymphocytic Leukaemia Lymphoplasmacytic Leukemia Small Lymphocytic Lymphoma Leukemia, Chronic Lymphatic B-Cell Chronic Lymphocytic Leukaemia Chronic Lymphatic Leukaemia Lymphoplasmacytic Leukaemia B Cell Chronic Lymphocytic Leukemia Chronic B-Cell Lymphocytic Leukemia Leukemia, Lymphocytic, Chronic B-Cll Chronic Lymphoid Leukemia Leukemia Lymphocytic Chronic Lymphoma Small Lymphocytic Leukemia, Lymphocytic, Chronic, B-Cell
Amyloidosis	Amyloid Disease Amyloid Amyloid Degeneration Amyloidosis Nos Amyloid Deposition Amyloid Infiltration Idiopathic Amyloidosis Hyaloid Degeneration Lardaceous Degeneration
Plasma Cell Leukemia	Plasma Cell Leukaemia Leukemia, Plasma Cell Plasmacytic Leukaemia Plasmacytic Leukemia Pcl Plasma Cell Leukaemia, Nos Leukemic Plasma Cell Plasma Cell Leukaemia Without Mention Of Remission
Systemic Lupus Erythematosus	Lupus Nephritis SLE Disseminated Lupus Erythematosus Systemic Lupus Erythematosus, Susceptibility To Lupus Erythematosus, Systemic Lupus Nephritis, Susceptibility To Libman-Sacks Disease Systemic Lupus Erythematosus Susceptibility To Sle - Lupus Erythematosus, Systemic Le Syndrome Lupus Lupus Erythematosus Systemic Lupus Erythematosus, Systemic, Susceptibility To Lupus Vulgaris Lupus Erythematosus, Discoid Lupus Erythematosus Systemic Lupus Erythematosus Nos Sle - [Systemic Lupus Erythematosus]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99844	Davoceticept		99.9%	Phase 1

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS16348	IGHG1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25153	Ighg1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	IGHG1	RGD	RGD:1359539