IFT57 (HIPPI) Antibody (YA8300)
(Synonyms: ESRRBL1; HIPPI; MHS4R2)IFT57 (HIPPI) Antibody (YA8300) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to IFT57 (HIPPI).
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Host:
Mouse
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Isotype:
IgG
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Application:
WB, IHC-P, ICC/IF
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Reactivity :
Human, Mouse, Rat
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Formulation:
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Conjugation:
Non-conjugated
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Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
|---|---|---|---|
| Dilution Ratio | 1:1000-2000 | 1:50-250 | 1:100-250 |
Product Details
IFT57 (HIPPI) Antibody (YA8300) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to IFT57 (HIPPI).
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman, Mouse, Rat
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Calculated Molecular Weight Predicted band size: 49.1 kDa
Full length human recombinant protein of human IFT57 produced in HEK293T cell.
Endogenous
Affinity purified
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Shipping
Shipping with blue ice.
Background
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Function
IFT57 is required for the formation of cilia. Plays an indirect role in sonic hedgehog signaling, cilia being required for all activity of the hedgehog pathway. Has pro-apoptotic function via its interaction with HIP1, leading to recruit caspase-8 (CASP8) and trigger apoptosis. Has the ability to bind DNA sequence motif 5'-AAAGACATG-3' present in the promoter of caspase genes such as CASP1, CASP8 and CASP10, suggesting that it may act as a transcription regulator; however the relevance of such function remains unclear
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Subcellular Localization
Cell projection, cilium,Cytoplasm, cytoskeleton, cilium basal body
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Expression
Tissue_Specificity: Present in many tissues such as brain, thymus, lymph node, lung, liver, skin and kidney (at protein level) -
Isoforms & Post-Translational Modification
Q9NWB7: 429 amino acids, molecular weight 49108 Da.
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Subunit
Component of the IFT complex B, at least composed of IFT20, IFT22, IFT25, IFT27, IFT46, IFT52, TRAF3IP1/IFT54, IFT57, IFT74, IFT80, IFT81, and IFT88 (By similarity)
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SwissProt ID
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Synonyms
ESRRBL1; HIPPI; MHS4R2
Documentation
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