IL-31 Antibody (YA7043)

Cat. No.: HY-P87360: Data Sheet User Guide for Antibodies
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IL-31 Antibody (YA7043) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to IL-31.

For research use only. We do not sell to patients.

Size	Price	Stock
20 μL		Ask For Quote & Lead Time
50 μL		Ask For Quote & Lead Time
100 μL		Ask For Quote & Lead Time

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Documentation

Description

IL-31 Antibody (YA7043) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to IL-31.

Host

Mouse

Clonality

Monoclonal

Molecular Weight

Predicted band size: 18 kDa;

Observed band size: 18 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.

Species Reactivity

Human

SwissProt ID

Q6EBC2

Immunogen

Recombinant protein within Human Interleukin 31 aa 1-164 / 164.

Application &
Dilution Ratio

Application	Dilution Ratio
WB WB: Western Blot	1:2000
ELISA ELISA: Enzyme Linked Immunosorbent Assay	1:5000-1:10000

Sensitivity	Endogenous	Purity	Protein A affinity purified.
Conjugation	Non-conjugated	Modification	Unmodified
Isotype	IgG2a

Appearance

Liquid

Formulation

Supplied in 1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Background

Function：Activates STAT3 and possibly STAT1 and STAT5 through the IL31 heterodimeric receptor composed of IL31RA and OSMR (PubMed:15184896). May function in skin immunity (PubMed:15184896). Enhances myeloid progenitor cell survival in vitro (By similarity). Induces RETNLA and serum amyloid A protein expression in macrophages (By similarity)

Subcellular Localization：Secreted

Expression：
Tissue_Specificity: Detected at low levels in testis, bone marrow, skeletal muscle, kidney, colon, thymus, small intestine and trachea
Induction: Up-regulated in skin homing T-cells of patients with atopic dermatitis (AD) and in activated circulating T-cells. Up-regulated in lesional biopsies of patients with allergic contact dermatitis (ACD)

Synonyms

IL 31 antibody; IL-31 antibody; IL31 antibody; IL31_HUMAN antibody; Interleukin 31 antibody; Interleukin-31 antibody

Documentation

User Guide for Antibodies (1077 KB)