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KLF15 Antibody (YA4561)(PBS only)

(Synonyms: KKLF; DKFZp779M1320)

KLF15 Antibody (YA4561) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to KLF15.

For research use only. We do not sell to patients.
  • Host:

    Mouse

  • Isotype:

    IgG1

  • Application:

    WB, ELISA

  • Reactivity :

    Human

  • Formulation:

    Supplied in PBS, pH 7.4.

  • Conjugation:
    Non-conjugated
  • KLF15 Antibody (YA4561)(PBS only) Product Image
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Use of MCE Products

Applications

Application
WB Info
WB: Western Blot
ELISA Info
ELISA: Enzyme Linked Immunosorbent Assay
Dilution Ratio 1:500-1:2000 1:10000

Product Details

Description

KLF15 Antibody (YA4561) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to KLF15.

  • Host Mouse
  • Species Reactivity
    Human
  • Observed Molecular Weight
    Observed band size: 44 kDa Info
    Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
  • Calculated Molecular Weight Predicted band size: 44 kDa
Immunogen

Purified recombinant fragment of human KLF15 aa 1-416.

Purification

affinity purified.

Conjugation

Non-conjugated

Isotype

IgG1

Product Properties

  • Appearance

    Liquid

  • Formulation

    Supplied in PBS, pH 7.4.

  • Storage & Stability

    Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

  • Shipping

    Shipping with blue ice.

Background

  • Function

    KLF15 transcriptional regulator that binds to the GA element of the CLCNKA promoter. Binds to the KCNIP2 promoter and regulates KCNIP2 circadian expression in the heart. Is a repressor of CCN2 expression, involved in the control of cardiac fibrosis. It is also involved in the control of cardiac hypertrophy acting through the inhibition of MEF2A and GATA4. Involved in podocyte differentiation. Inhibits MYOCD activity. Is a negative regulator of TP53 acetylation. Inhibits NF-kappa-B activation through repression of EP300-dependent RELA acetylation

  • Subcellular Localization

    Nucleus

  • Expression


    Tissue_specificity:It is highly expressed in the liver, skeletal muscle, and kidneys. It is also expressed in cardiomyocytes. Expression is significantly reduced in cardiac tissues with non-ischemic cardiomyopathy and aortic aneurysms, as well as in glomerular diseases. It is not expressed in bone marrow or lymphoid tissues.

    Induction:In podocytes, up-regulated by retinoic acid

  • Subunit

    Interacts with MYOCD and EP300

  • SwissProt ID

    Q9UIH9

  • Gene ID
    28999 [NCBI]
  • Synonyms

    KKLF; DKFZp779M1320

KLF15 Antibody (YA4561)(PBS only) Related Classifications

MOQ
Minimum order quantity
100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
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  • KLF15 Antibody (YA4561)(PBS only) Product Image