LPGAT1 Antibody
(Synonyms: Acyl-CoA:lysophosphatidylglycerol acyltransferase 1)LPGAT1 Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to LPGAT1.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB
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Reactivity :
Human, Mouse
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Formulation:
Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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|---|---|
| Dilution Ratio | 1:2000 |
Product Details
LPGAT1 Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to LPGAT1.
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Host Rabbit
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Species ReactivityHuman, Mouse
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Calculated Molecular Weight Predicted band size: 43.1 kDa
aa144-177 from the Central region of human LPGAT1.
Affinity purified
Non-conjugated
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
LPGAT1 is a Lysophospholipid acyltransferase involved in fatty acyl chain remodeling of glycerophospholipids in the endoplasmic reticulum membrane (By similarity). Selectively catalyzes the transfer and esterification of saturated long-chain fatty acids from acyl-CoA to the sn-1 position of 1-lyso-2-acyl phosphatidylethanolamines (1-lyso-PE, LPE), with a preference for stearoyl CoA over palmitoyl CoA as acyl donor. Acts in concert with an unknown phospholipase A1 to convert palmitate phosphatidylethanolamine (PE) species into stearate ones. Provides substrates to the PE methylation pathway, controlling stearate/palmitate composition of PE and phosphatidylcholine (PC) species with an overall impact on de novo hepatic lipid synthesis, body fat content and life span (By similarity). Can acylate lysophosphatidylglycerols (LPG) using various saturated fatty acyl-CoAs as acyl donors. Can also acylate monoacylglycerols with a preference for 2-monoacylglycerols over 1-monoacylglycerols (By similarity). Has no activity toward lysophosphatidic acids (LPA) (By similarity)[1][2].
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Subcellular Localization
Endoplasmic reticulum membrane
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Expression
Tissue_Specificity: Highly expressed in liver and placenta. Also expressed in peripheral blood, lung, kidney and brain. Detected at lower levels in colon. High expression is detected in brain and testis. -
Isoforms & Post-Translational Modification
LPGAT1 has an amino acid length of 370, molecular weight is 43089 Da.
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SwissProt ID
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Synonyms
Acyl-CoA:lysophosphatidylglycerol acyltransferase 1
Documentation
[1]. Kawana H, et al. Identification and characterization of LPLAT7 as an sn-1-specific lysophospholipid acyltransferase. J Lipid Res. 2022 Oct;63(10):100271. [Content Brief]
[2]. Yang Y, et al. Identification and characterization of a gene encoding human LPGAT1, an endoplasmic reticulum-associated lysophosphatidylglycerol acyltransferase. J Biol Chem. 2004 Dec 31;279(53):55866-74. [Content Brief]
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