Mad2L1 Antibody (YA7284)
Mad2L1 Antibody (YA7284) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Mad2L1.
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Host:
Rabbit
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Isotype:
IgG
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Application:
ICC/IF
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Reactivity :
Human
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Formulation:
Supplied in 0.01M tris buffered saline (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
|---|---|
| Dilution Ratio | 1:100-500 |
Product Details
Mad2L1 Antibody (YA7284) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Mad2L1.
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Host Rabbit
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Clonality Recombinant,Monoclonal
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Species ReactivityHuman
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Calculated Molecular Weight Predicted band size: 23 kDa;
Recombinant human Mad2L1 protein
Endogenous
affinity purified by Protein A
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Liquid
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Formulation
Supplied in 0.01M tris buffered saline (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
Mad2L1 component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. In the closed conformation (C-MAD2) forms a heterotetrameric complex with MAD1L1 at unattached kinetochores during prometaphase, the complex recruits open conformation molecules of MAD2L1 (O-MAD2) and then promotes the conversion of O-MAD2 to C-MAD2. Required for the execution of the mitotic checkpoint which monitors the process of kinetochore-spindle attachment and inhibits the activity of the anaphase promoting complex by sequestering CDC20 until all chromosomes are aligned at the metaphase plate[1][2][3][4].
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Subcellular Localization
Nucleus,Chromosome, centromere, kinetochore,Cytoplasm,Cytoplasm, cytoskeleton, spindle pole
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Isoforms & Post-Translational Modification
Q13257 has two isomers: Q13257-1: 23510 Da (predicted); Q13257-2: 10335 Da (predicted).
Phosphorylated on multiple serine residues -
Subunit
Monomer and homodimer (PubMed:18022367, PubMed:18318601)
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SwissProt ID
Documentation
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