Meckelin Antibody (YA3057)(PBS only)
(Synonyms: MKS3; JBTS6; NPHP11; TNEM67; MECKELIN)Meckelin Antibody (YA3057) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Meckelin.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, ICC/IF
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Reactivity :
Human
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Formulation:
Supplied in PBS, pH 7.4.
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Conjugation:
Non-conjugated
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
|---|---|---|
| Dilution Ratio | 1:500-1:1000 | 1:50-1:200 |
Product Details
Meckelin Antibody (YA3057) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Meckelin.
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Host Rabbit
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Species ReactivityHuman
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Observed Molecular WeightObserved band size: 112 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 112 kDa
A synthetic peptide of human Meckelin aa34-47.
Affinity Purified
Non-conjugated
IgG
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS, pH 7.4.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
Meckelin is required for ciliary structure and function. Part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition. Involved in centrosome migration to the apical cell surface during early ciliogenesis. Involved in the regulation of cilia length and appropriate number through the control of centrosome duplication. Is a key regulator of stereociliary bundle orientation. Required for epithelial cell branching morphology. Essential for endoplasmic reticulum-associated degradation (ERAD) of surfactant protein C (SFTPC). Involved in the negative regulation of canonical Wnt signaling, and activation of the non-canonical cascade stimulated by WNT5A. In non-canonical Wnt signaling, it may act as ROR2 coreceptor[1].
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Subcellular Localization
Cell membrane; Multi-pass membrane protein; Endoplasmic reticulum membrane; Multi-pass membrane protein; Cell projection, cilium; Cytoplasm, cytoskeleton, cilium basal body
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Expression
Tissue_specificity:Widely expressed in human tissues. Expressed at higher level in spinal cord -
Subunit
Homodimer (PubMed:34731008). Part of the tectonic-like complex (also named B9 complex) (By similarity). Interacts with DNAJB9, DNAJC10 and mutated SFTPC. Interacts with SYNE2 during the early establishment of cell polarity. Interacts (via C-terminus) with FLNA. Interacts with TMEM218 (PubMed:35137054). Interacts with WNT5A (PubMed:26035863, PubMed:34731008). Interacts with ROR2 (PubMed:26035863)
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SwissProt ID
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Synonyms
MKS3; JBTS6; NPHP11; TNEM67; MECKELIN
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Research Field
Tags & Cell Markers
Documentation
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