MINPP1 Antibody (YA8612)(PBS only)
(Synonyms: HIPER1; MINPP2; MIPP)MINPP1 Antibody (YA8612) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to MINPP1.
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Host:
Mouse
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Isotype:
IgG1
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Application:
WB, IHC-P, ICC/IF
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Reactivity :
Human
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Formulation:
Supplied in PBS, pH 7.4.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|---|---|
| Dilution Ratio | 1:4000 | 1:100 | 1:150 |
Product Details
MINPP1 Antibody (YA8612) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to MINPP1.
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Host Mouse
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Species ReactivityHuman
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Calculated Molecular Weight Predicted band size: 54.9 kDa
Full length human recombinant protein of human MINPP1 produced in HEK293T cell.
Affinity purified
Non-conjugated
IgG1
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS, pH 7.4.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
MINPP1 is a Multiple inositol polyphosphate phosphatase that hydrolyzes 1D-myo-inositol 1,3,4,5,6-pentakisphosphate (InsP5[2OH]) and 1D-myo-inositol hexakisphosphate (InsP6) to a range of less phosphorylated inositol phosphates. This regulates the availability of these various small molecule second messengers and metal chelators which control many aspects of cell physiology. Has a weak in vitro activity towards 1D-myo-inositol 1,4,5-trisphosphate which is unlikely to be physiologically relevant. By regulating intracellular inositol polyphosphates pools, which act as metal chelators, it may control the availability of intracellular calcium and iron, which are important for proper neuronal development and homeostasis. May have a dual substrate specificity, and function as a 2,3-bisphosphoglycerate 3-phosphatase hydrolyzing 2,3-bisphosphoglycerate to 2-phosphoglycerate. 2,3-bisphosphoglycerate (BPG) is formed as part of the Rapoport-Luebering glycolytic bypass and is a regulator of systemic oxygen homeostasis as the major allosteric effector of hemoglobin[1][2][3].
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Subcellular Localization
Endoplasmic reticulum lumen,Secreted,Cell membrane
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Expression
Tissue_Specificity: Widely expressed with highest levels in kidney, liver, cerebellum and placenta -
Isoforms & Post-Translational Modification
Q9UNW1 has four isomers: Q9UNW1-1: 55051 Da (predicted); Q9UNW1-2: 34661 Da (predicted); Q9UNW1-3: 31475 Da (predicted); Q9UNW1-4: 33100 Da (predicted).
N-glycosylated -
SwissProt ID
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Synonyms
HIPER1; MINPP2; MIPP
Documentation
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