MMAA Antibody (YA8592)
(Synonyms: cblA)MMAA Antibody (YA8592) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to MMAA.
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Host:
Mouse
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Isotype:
IgG2a
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Application:
IHC-P, ICC/IF
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Reactivity :
Human
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Formulation:
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Conjugation:
Non-conjugated
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Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
|---|---|---|
| Dilution Ratio | 1:150-500 | 1:100-250 |
Product Details
MMAA Antibody (YA8592) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to MMAA.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman
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Calculated Molecular Weight Predicted band size: 39 kDa
Full length human recombinant protein of human MMAA produced in HEK293T cell.
Endogenous
Affinity purified
Non-conjugated
Unmodified
IgG2a
Product Properties
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Appearance
Liquid
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Formulation
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
MMAA is a GTPase, binds and hydrolyzes GTP. Involved in intracellular vitamin B12 metabolism, mediates the transport of cobalamin (Cbl) into mitochondria for the final steps of adenosylcobalamin (AdoCbl) synthesis. Functions as a G-protein chaperone that assists AdoCbl cofactor delivery from MMAB to the methylmalonyl-CoA mutase (MMUT). Plays a dual role as both a protectase and a reactivase for MMUT. Protects MMUT from progressive inactivation by oxidation by decreasing the rate of the formation of the oxidized inactive cofactor hydroxocobalamin (OH2Cbl). Additionally acts a reactivase by promoting the replacement of OH2Cbl by the active cofactor AdoCbl, restoring the activity of MMUT in the presence and hydrolysis of GTP[1][2][3][4].
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Subcellular Localization
Mitochondrion,Cytoplasm
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Expression
Tissue_Specificity: Widely expressed. Highest expression is observed in liver and skeletal muscle -
Isoforms & Post-Translational Modification
Q8IVH4: 418 amino acids, molecular weight 46538 Da.
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Subunit
Homodimer (PubMed:20876572)
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SwissProt ID
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Synonyms
cblA
Documentation
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