Myelin Protein Zero Antibody (YA3278)
(Synonyms: P0; CHM; DSS; MPP; CMT1; CMT1B; CMT2I; CMT2J; CMT4E; CMTDI3; CMTDID; HMSNIB)Myelin Protein Zero Antibody (YA3278) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Myelin Protein Zero.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB
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Reactivity :
Rat
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Formulation:
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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|---|---|
| Dilution Ratio | 1:500-1:1000 |
Product Details
Myelin Protein Zero Antibody (YA3278) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Myelin Protein Zero.
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Host Rabbit
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Clonality Recombinant, Monoclonal
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Species ReactivityRat
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Observed Molecular WeightObserved band size: 28 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 28 kDa
Entrez Gene: 360871 Rat
SwissProt: Q6AYT8 Rat
Recombinant protein of human Myelin Protein Zero
Endogenous
Affinity Purified
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Liquid
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Formulation
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
Myelin Protein Zero cell surface receptor, which is involved in signal transduction processes. Recruits PTPN11/SHP-2 to the cell membrane and is a putative substrate of PTPN11/SHP-2. Is a major receptor for concanavalin-A (ConA) and is involved in cellular signaling induced by ConA, which probably includes Src family tyrosine-protein kinases. Isoform 3 seems to have a dominant negative role; it blocks tyrosine phosphorylation of MPZL1 induced by ConA. Isoform 1, but not isoform 2 and isoform 3, may be involved in regulation of integrin-mediated cell motility
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Subcellular Localization
Membrane; Single-pass type I membrane protein
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Expression
Tissue_specificity:This gene is widely expressed in the heart, placenta, kidneys, and pancreas, with the highest expression levels found in these regions. Isomer 3 is relatively abundant in hematopoietic tissues and the fetal liver. Isomers 1 and 3 are expressed in CD14-peripheral blood monocytes and pre-B cell progenitor cells. Isomer 3 appears to be the dominant isomer in CD34-promyelocytes and early monocytes. During monocyte differentiation, the expression level of isomer 3 decreases, while the expression level of isomer 1 increases. Isomer 1 is abundant in stromal cells and less abundant in umbilical vein endothelial cells and erythroid progenitor cells. Isomer 2 is expressed in erythroid progenitor cell lines. -
Subunit
Interacts with phosphorylated PTPN11/SHP-2
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SwissProt ID
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Synonyms
P0; CHM; DSS; MPP; CMT1; CMT1B; CMT2I; CMT2J; CMT4E; CMTDI3; CMTDID; HMSNIB
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Research Field
Signal Transduction
Documentation
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