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  4. Monoclonal Antibodies Recombinant Antibodies
  5. Myelin Protein Zero Antibody (YA3278)

Myelin Protein Zero Antibody (YA3278)

Cat. No.: HY-P83533
User Guide for Antibodies Technical Support

Myelin Protein Zero Antibody (YA3278) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Myelin Protein Zero.

For research use only. We do not sell to patients.

Size Price Stock Quantity
20 μL Get quote 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks
50 μL Get quote 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks
100 μL Get quote 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks
250 μL   Get quote  
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Top Publications Citing Use of Products
  • WB: Western Blot;
  • IHC-P: Immunohistochemistry-Paraffin;
  • IHC-F: Immunohistochemistry-Frozen;
  • ICC/IF: Immunocytochemistry/Immunofluorescence;
  • IF-Tissue: Immunofluorescence-Tissue;
  • mIHC: Multiplex Immunohistochemical;
  • IP: Immunoprecipitation;
  • ChIP: Chromatin Immunoprecipitation;
  • FC: Flow Cytometry;
  • ELISA: Enzyme Linked Immunosorbent Assay

  • Product Detail

  • Background

  • Documentation

Description

Myelin Protein Zero Antibody (YA3278) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Myelin Protein Zero.
Host

Rabbit
Clonality

Recombinant, Monoclonal
Molecular Weight
Predicted band size: 28 kDa;
Observed band size: 28 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
Species Reactivity
Rat
SwissProt ID
Gene ID
Immunogen

Recombinant protein of human Myelin Protein Zero
Application &
Dilution Ratio
Application Dilution Ratio
WB
WB: Western Blot
1:500-1:1000
Sensitivity Endogenous Purity Affinity Purified
Conjugation Non-conjugated Modification Unmodified
Isotype IgG  
Appearance

Liquid
Formulation

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping

Shipping with blue ice.
Background
Function：Cell surface receptor, which is involved in signal transduction processes. Recruits PTPN11/SHP-2 to the cell membrane and is a putative substrate of PTPN11/SHP-2. Is a major receptor for concanavalin-A (ConA) and is involved in cellular signaling induced by ConA, which probably includes Src family tyrosine-protein kinases. Isoform 3 seems to have a dominant negative role; it blocks tyrosine phosphorylation of MPZL1 induced by ConA. Isoform 1, but not isoform 2 and isoform 3, may be involved in regulation of integrin-mediated cell motility
Subcellular Localization：Membrane; Single-pass type I membrane protein
Expression：
Tissue_specificity:This gene is widely expressed in the heart, placenta, kidneys, and pancreas, with the highest expression levels found in these regions. Isomer 3 is relatively abundant in hematopoietic tissues and the fetal liver. Isomers 1 and 3 are expressed in CD14-peripheral blood monocytes and pre-B cell progenitor cells. Isomer 3 appears to be the dominant isomer in CD34-promyelocytes and early monocytes. During monocyte differentiation, the expression level of isomer 3 decreases, while the expression level of isomer 1 increases. Isomer 1 is abundant in stromal cells and less abundant in umbilical vein endothelial cells and erythroid progenitor cells. Isomer 2 is expressed in erythroid progenitor cell lines.
Subunit：Interacts with phosphorylated PTPN11/SHP-2
Database

Entrez Gene: 360871 Rat

SwissProt: Q6AYT8 

Research Field

Signal Transduction
Synonyms
P0; CHM; DSS; MPP; CMT1; CMT1B; CMT2I; CMT2J; CMT4E; CMTDI3; CMTDID; HMSNIB
Documentation
User Guide for Antibodies (1077 KB)

Myelin Protein Zero Antibody (YA3278) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Myelin Protein Zero Antibody (YA3278)
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