MyT1L Antibody (YA6668)

Cat. No.: HY-P86975: Data Sheet User Guide for Antibodies
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MyT1L Antibody (YA6668) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to MyT1L.

For research use only. We do not sell to patients.

Size		Stock
50 μL		Get quote
100 μL		Get quote

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Documentation

Description

MyT1L Antibody (YA6668) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to MyT1L.

Host

Rabbit

Clonality

Recombinant,Monoclonal

Molecular Weight

Predicted band size: 133 kDa;

Observed band size: 170 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.

Species Reactivity

Human, Mouse, Rat Predicted Reactivity: Cynomolgus monkey

Note: The predicted reactivity is for reference only and should not be considered a guarantee of product performance.

SwissProt ID

Q9UL68

Gene ID

23040 [NCBI]

Immunogen

Recombinant protein within human MyT1L aa 151-500.

Application &
Dilution Ratio

Application	Dilution Ratio
WB WB: Western Blot	1:2000
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:1000
IHC-F IHC-F: Immunohistochemistry-Frozen	1:500

Purity	affinity purified.	Conjugation	Non-conjugated
Modification	Unmodified	Isotype	IgG

Appearance

Liquid

Formulation

Supplied in PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Background

Function：Transcription factor that plays a key role in neuronal differentiation by specifically repressing expression of non-neuronal genes during neuron differentiation. In contrast to other transcription repressors that inhibit specific lineages, mediates repression of multiple differentiation programs. Also represses expression of negative regulators of neurogenesis, such as members of the Notch signaling pathway, including HES1. The combination of three transcription factors, ASCL1, POU3F2/BRN2 and MYT1L, is sufficient to reprogram fibroblasts and other somatic cells into induced neuronal (iN) cells in vitro. Directly binds the 5'-AAGTT-3' core motif present on the promoter of target genes and represses transcription by recruiting a multiprotein complex containing SIN3B. The 5'-AAGTT-3' core motif is absent from the promoter of neural genes

Subcellular Localization：Nucleus,Chromosome

Isoforms & Post-Translational Modification：Q9UL68 has three isomers: Q9UL68-1: 133043 Da (predicted); Q9UL68-3: 20620 Da (predicted); Q9UL68-4: 132858 Da (predicted).

Subunit：Interacts with SIN3B

Synonyms

Myelin transcription factor 1-like protein antibody; MyT1-L antibody; MyT1L antibody; MYT1L_HUMAN antibody; neural zinc finger transcription factor 1 antibody;

Documentation

User Guide for Antibodies (1077 KB)