MyT1L Antibody (YA6668)
(Synonyms: Myelin transcription factor 1-like protein antibody; MyT1-L antibody; MyT1L antibody; MYT1L_HUMAN antibody; neural zinc finger transcription factor 1 antibody; )MyT1L Antibody (YA6668) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to MyT1L.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IHC-P, IHC-F
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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IHC-F
IHC-F: Immunohistochemistry-Frozen
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|---|---|---|---|
| Dilution Ratio | 1:2000 | 1:1000 | 1:500 |
Product Details
MyT1L Antibody (YA6668) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to MyT1L.
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Host Rabbit
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Clonality Recombinant,Monoclonal
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Species ReactivityHuman, Mouse, Rat Predicted Reactivity: Cynomolgus monkey
Note: The predicted reactivity is for reference only and should not be considered a guarantee of product performance.
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Observed Molecular WeightObserved band size: 170 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 133 kDa
Recombinant protein within human MyT1L aa 151-500.
affinity purified.
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
MyT1L transcription factor that plays a key role in neuronal differentiation by specifically repressing expression of non-neuronal genes during neuron differentiation. In contrast to other transcription repressors that inhibit specific lineages, mediates repression of multiple differentiation programs. Also represses expression of negative regulators of neurogenesis, such as members of the Notch signaling pathway, including HES1. The combination of three transcription factors, ASCL1, POU3F2/BRN2 and MYT1L, is sufficient to reprogram fibroblasts and other somatic cells into induced neuronal (iN) cells in vitro. Directly binds the 5'-AAGTT-3' core motif present on the promoter of target genes and represses transcription by recruiting a multiprotein complex containing SIN3B. The 5'-AAGTT-3' core motif is absent from the promoter of neural genes
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Subcellular Localization
Nucleus,Chromosome
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Isoforms & Post-Translational Modification
Q9UL68 has three isomers: Q9UL68-1: 133043 Da (predicted); Q9UL68-3: 20620 Da (predicted); Q9UL68-4: 132858 Da (predicted).
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Subunit
Interacts with SIN3B
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SwissProt ID
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Synonyms
Myelin transcription factor 1-like protein antibody; MyT1-L antibody; MyT1L antibody; MYT1L_HUMAN antibody; neural zinc finger transcription factor 1 antibody;
Documentation
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