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MYT1L - myelin transcription factor 1 like Gene

Also Known as NZF1; MRD39; myT1-L; ZC2H2C2; ZC2HC4B

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 23040

About MYT1L

Cytogenetic location: 2p25.3 Genomic coordinates (GRCh38): 2:1,789,113-2,331,275 (from NCBI)

This gene has 70 transcripts (splice variants), 288 orthologues, 5 paralogues and is associated with 4 phenotypes. Biased expression in brain (RPKM 9.8) and testis (RPKM 1.0).

Summary

This gene encodes a member of the zinc finger superfamily of transcription factors whose expression, thus far, has been found only in neuronal tissues. The encoded protein belongs to a novel class of cystein-cystein-histidine-cystein zinc finger proteins that function in the developing mammalian central nervous system. Forced expression of this gene in combination with the basic helix-loop-helix transcription factor NeuroD1 and the transcription factors POU class 3 homeobox 2 and achaete-scute family basic helix-loop-helix transcription factor 1 can convert fetal and postnatal human fibroblasts into induced neuronal cells, which are able to generate action potentials. Mutations in this gene have been associated with an autosomal dominant form of cognitive disability and with autism spectrum disorder. Alternative splicing results in multiple variants. [provided by RefSeq, Jul 2017]

MYT1L Products (10)

mRNA	Protein	Name
NM_001303052.2	NP_001289981.1	myelin transcription factor 1-like protein isoform 1
NM_001329844.2	NP_001316773.1	myelin transcription factor 1-like protein isoform 1
NM_001329845.1	NP_001316774.1	myelin transcription factor 1-like protein isoform 1
NM_001329846.3	NP_001316775.1	myelin transcription factor 1-like protein isoform 3
NM_001329847.2	NP_001316776.1	myelin transcription factor 1-like protein isoform 2
NM_001329848.1	NP_001316777.1	myelin transcription factor 1-like protein isoform 2
NM_001329849.3	NP_001316778.1	myelin transcription factor 1-like protein isoform 4
NM_001329851.3	NP_001316780.1	myelin transcription factor 1-like protein isoform 5
NM_001329852.3	NP_001316781.1	myelin transcription factor 1-like protein isoform 6
NM_015025.4	NP_055840.2	myelin transcription factor 1-like protein isoform 2

MYT1L Protein Structure

zf-C2HC

MYT1

zf-C2HC

0
200
400
600
800
1000
1186 a.a.

Protein Preferred Names	Protein Names
myelin transcription factor 1-like protein	neural zinc finger transcription factor 1

MYT1L Antibodies

Cat. No.	상품명	신청	Reactivity
HY-P86975	MyT1L Antibody (YA6668)	WB, IHC-P, IHC-F	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Intellectual Developmental Disorder, Autosomal Dominant 39	MRD39 Mental Retardation, Autosomal Dominant 39 Mental Retardation, Autosomal Dominant 39, And Obesity Autosomal Dominant Intellectual Developmental Disorder 39 Autosomal Dominant Mental Retardation 39 Autosomal Dominant Non-Syndromic Intellectual Disability 39 Mental Retardation, Autosomal Dominant, Type 39
Non-Specific Syndromic Intellectual Disability	Complex Neurodevelopmental Disorder
Autosomal Dominant Non-Syndromic Intellectual Disability
Alternating Exotropia	Exotropia
Autism Spectrum Disorder	Asd Autism Spectrum Disorders Autistic Continuum Pervasive Developmental Disorder Pervasive Development Disorder Autistic Behavior Autistic Disorder Autistic Autistic Disorder Of Childhood Onset Infantile Autism Childhood Autism Kanner Syndrome Pervasive Developmental Delay Nos Pervasive Developmental Disorder, Not Otherwise Specified
Autism	Autistic Disorder Autism Susceptibility 1 Childhood Autism Autistic Disorder Of Childhood Onset Infantile Autism Kanner'S Syndrome Autistic
Fragile X Syndrome	FXS Martin-Bell Syndrome Fraxa Syndrome Marker X Syndrome X-Linked Mental Retardation And Macroorchidism Fragile X Mental Retardation Syndrome Fra Syndrome Mental Retardation, X-Linked, Associated With Marxq28 X-Linked Intellectual Disability And Macroorchidism Frax Syndrome Symptomatic Form Of Fragile X Syndrome In Female Carriers Fragile-X Syndrome Fraxe Syndrome
Neuropathy, Hereditary Sensory And Autonomic, Type Iii	Familial Dysautonomia Riley-Day Syndrome Dysautonomia, Familial HSAN3 Hsan Iii Fd Hereditary Sensory And Autonomic Neuropathy Type Iii Dys Hereditary Sensory And Autonomic Neuropathy 3 Riley Day Syndrome Familial Autonomic Nervous Dysfunction Hereditary Sensory Autonomic Neuropathy Type Iii Hsan 3 Hsn 3 Hereditary Sensory Neuropathy Type 3 Hsan Type Iii Hsn-Iii Hereditary Sensory And Autonomic Neuropathy Type 3 Neuropathy, Hereditary Sensory And Autonomic, 3 Hsn Iii Dysautonomia Familial Neuropathy, Sensory And Autonomic, Hereditary, Type Iii Hsan3 - [Hereditary Sensory And Autonomic Neuropathy Type 3]
Schizophrenia	SCZD Schizophrenia With Or Without An Affective Disorder Schizophrenia 12 Schizophrenia, Susceptibility To Schizophrenia-1 Dementia Praecox Schizophrenia 1
Attention Deficit-Hyperactivity Disorder	Attention Deficit Hyperactivity Disorder ADHD Attention Deficit Disorder Attention Deficit-Hyperactivity Disorder, Susceptibility To Attention Deficit Disorder With Hyperactivity Hyperkinetic Disorder Hyperactivity Of Childhood Attention-Deficit/Hyperactivity Disorder Add Addh Attention Deficit Attention Deficit Disorder Of Childhood With Hyperactivity Attention Deficit Disorder With Hyperactivity Syndrome Hyperkinetic Syndrome Attention-Deficit Hyperactivity Disorder Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type Disturbance Of Activity And Attention Disorder Of Activity And Attention Adhd - [Attention Deficit Hyperactivity Disorder] Hyperkinetic Disorders Disorder Of Activity And Attention With Hyperkinesia Attention Deficit Syndrome With Hyperactivity

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	상품명	효과	Purity	Rare Diseases
HY-RS08974	MYT1L Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21661	Myt1l Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28179	Myt1l Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	MYT1L	VGNC	VGNC:43592
Bos taurus	MYT1L	VGNC	VGNC:59198
Mus musculus	MYT1L	MGD	MGI:1100511
Rattus norvegicus	MYT1L	RGD	RGD:620550
Macaca mulatta	MYT1L	VGNC	VGNC:99698
Others	MYT1L	NCBI