BNP Antibody (YA1001)
(Synonyms: NPPB; Natriuretic peptides B; Gamma-brain natriuretic peptide)BNP Antibody (YA1001) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to BNP.
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Host:
Mouse
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Isotype:
IgG
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Application:
ELISA
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Reactivity :
Human
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Formulation:
Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
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Conjugation:
Non-conjugated
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Applications
| Application |
ELISA
ELISA: Enzyme Linked Immunosorbent Assay
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|---|---|
| Dilution Ratio | 1:10000 |
Product Details
BNP Antibody (YA1001) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to BNP.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman
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Observed Molecular WeightObserved band size: 30 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 15 kDa
Synthetic peptide derived from human NT-proBNP.
Endogenous
Affinity Purified
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
BNP is a Cardiac hormone that plays a key role in mediating cardio-renal homeostasis. May also function as a paracrine antifibrotic factor in the heart. Acts by specifically binding and stimulating NPR1 to produce cGMP, which in turn activates effector proteins that drive various biological responses. Involved in regulating the extracellular fluid volume and maintaining the fluid-electrolyte balance through natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. Binds the clearance receptor NPR3; May affect cardio-renal homeostasis. Able to promote the production of cGMP although its potency is very low compared to brain natriuretic peptide 32; May have a role in cardio-renal homeostasis. Able to promote the production of cGMP[1][2][3][4][5][6][7][8].
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Subcellular Localization
Secreted; Secreted; Secreted; Secreted
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Expression
Tissue_specificity:Protein levels were detected in the atria (PubMed: 2136732, PubMed: 2138890) . Protein levels were detected in the distal convoluted tubule cells of the kidney (PubMed: 9794555) . -
SwissProt ID
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Synonyms
NPPB; Natriuretic peptides B; Gamma-brain natriuretic peptide
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Research Field
Neuroscience
Documentation
References
[1]. Koller KJ, et al. Selective activation of the B natriuretic peptide receptor by C-type natriuretic peptide (CNP). Science. 1991 Apr 5;252(5002):120-3. [Content Brief]
[2]. Heublein DM, et al. Immunoreactivity and guanosine 3',5'-cyclic monophosphate activating actions of various molecular forms of human B-type natriuretic peptide. Hypertension. 2007 May;49(5):1114-9. [Content Brief]
[3]. Yoshimura M, et al. Hemodynamic, renal, and hormonal responses to brain natriuretic peptide infusion in patients with congestive heart failure. Circulation. 1991 Oct;84(4):1581-8. [Content Brief]
[4]. Jensen KT, et al. Effect of BNP on renal hemodynamics, tubular function and vasoactive hormones in humans. Am J Physiol. 1998 Jan;274(1):F63-72. [Content Brief]
[5]. Liang F, et al. Evidence for functional heterogeneity of circulating B-type natriuretic peptide. J Am Coll Cardiol. 2007 Mar 13;49(10):1071-8. [Content Brief]
[6]. Ralat LA, et al. Insulin-degrading enzyme modulates the natriuretic peptide-mediated signaling response. J Biol Chem. 2011 Feb 11;286(6):4670-9. [Content Brief]
[7]. Huntley BK, et al. Pro-B-type natriuretic peptide-1-108 processing and degradation in human heart failure. Circ Heart Fail. 2015 Jan;8(1):89-97. [Content Brief]
[8]. He XL, et al. Structural determinants of natriuretic peptide receptor specificity and degeneracy. J Mol Biol. 2006 Aug 25;361(4):698-714. [Content Brief]
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