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NPTN Antibody (YA8062)(PBS only)

(Synonyms: GP55; GP65; np55; np65; SDFR1; SDR1)

NPTN Antibody (YA8062) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to NPTN.

For research use only. We do not sell to patients.
  • Host:

    Mouse

  • Isotype:

    IgG1

  • Application:

    IHC-P, ICC/IF

  • Reactivity :

    Human, Dog, Rat, Monkey

  • Formulation:

    Supplied in PBS, pH 7.4.

  • Conjugation:
    Non-conjugated
  • NPTN Antibody (YA8062)(PBS only) Product Image
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Use of MCE Products

Applications

Application
IHC-P Info
IHC-P: Immunohistochemistry-Paraffin
ICC/IF Info
ICC/IF: Immunocytochemistry/
Immunofluorescence
Dilution Ratio 1:150-500 1:100-250

Product Details

Description

NPTN Antibody (YA8062) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to NPTN.

  • Host Mouse
  • Species Reactivity
    Human, Dog, Rat, Monkey
  • Calculated Molecular Weight Predicted band size: 28.7 kDa
Immunogen

Full length human recombinant protein of human NPTN produced in HEK293T cell.

Purification

Affinity purified

Conjugation

Non-conjugated

Isotype

IgG1

Product Properties

  • Appearance

    Liquid

  • Formulation

    Supplied in PBS, pH 7.4.

  • Storage & Stability

    Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

  • Shipping

    Shipping with blue ice.

Background

  • Function

    NPTN is a Probable homophilic and heterophilic cell adhesion molecule involved in long term potentiation at hippocampal excitatory synapses through activation of p38MAPK. May also regulate neurite outgrowth by activating the FGFR1 signaling pathway. May play a role in synaptic plasticity. Also acts as a chaperone for ATP2B1; stabilizes ATP2B1 and increases its ATPase activity. Promotes localization of XKR8 at the cell membrane[1][2].

  • Subcellular Localization

    Cell membrane,Postsynaptic density

  • Expression


    Tissue_Specificity: Isoform 1 is ubiquitously expressed. Isoform 2 is expressed in brain cortex and cerebellum (at protein level)

  • Isoforms & Post-Translational Modification

    Q9Y639 has 5 isomers: Q9Y639-2: 44387 Da (predicted); Q9Y639-1: 31291 Da (predicted); Q9Y639-3: 30835 Da (predicted); Q9Y639-4: 37792 Da (predicted); Q9Y639-5: 43931 Da (predicted).

  • Subunit

    Interacts with ATP2B1; this interaction stabilizes ATP2B1 and increases ATPase activity; this interaction controls T cell calcium homeostasis following T cell activation (PubMed:30190470)

  • SwissProt ID

    Q9Y639

  • Synonyms

    GP55; GP65; np55; np65; SDFR1; SDR1

NPTN Antibody (YA8062)(PBS only) Related Classifications

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100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
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  • NPTN Antibody (YA8062)(PBS only) Product Image