Trk C Antibody (YA4307)

Cat. No.: HY-P84610: Data Sheet User Guide for Antibodies
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Trk C Antibody (YA4307) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Trk C.

For research use only. We do not sell to patients.

Size	Stock	Quantity
20 μL	Get quote 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
50 μL	Get quote 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
100 μL	Get quote 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
250 μL	Get quote

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Documentation

Description

Trk C Antibody (YA4307) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Trk C.

Host

Mouse

Clonality

Monoclonal Antibody

Molecular Weight

Predicted band size: 94 kDa;

Observed band size: 94 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.

Species Reactivity

Human

SwissProt ID

Q16288

Gene ID

4916 [NCBI]

Immunogen

Purified recombinant extracellular fragment of human NTRK3 (aa32-429) fused with hIgGFc tag expressed in HEK293 cells.

Application &
Dilution Ratio

Application	Dilution Ratio
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:200-1:1000
ELISA ELISA: Enzyme Linked Immunosorbent Assay	1:10000

Purity	affinity purified.	Conjugation	Non-conjugated
Modification	Unmodified	Isotype	IgG1

Appearance

Liquid

Formulation

Supplied in PBS with 0.05% sodium azide.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Background

Function：Receptor tyrosine kinase involved in nervous system and probably heart development. Upon binding of its ligand NTF3/neurotrophin-3, NTRK3 autophosphorylates and activates different signaling pathways, including the phosphatidylinositol 3-kinase/AKT and the MAPK pathways, that control cell survival and differentiation

Subcellular Localization：Membrane; Single-pass type I membrane protein

Expression：
Tissue_specificity:It is widely expressed, but mainly found in neural tissue. Isomer 2 is expressed at a higher level in the human brain than in the fetal brain.

Isoforms & Post-Translational Modification：Q16288 has 5 isomers: Q16288-1: 94428 Da (predicted); Q16288-2: 68452 Da (predicted); Q16288-3: 92801 Da (predicted); Q16288-4: 93460 Da (predicted); Q16288-5: 91833 Da (predicted).
Ligand-mediated auto-phosphorylation

Subunit：Exists in a dynamic equilibrium between monomeric (low affinity) and dimeric (high affinity) structures (By similarity). Binds SH2B2. Interacts with SQSTM1 and KIDINS220 (By similarity). Interacts with PTPRS (PubMed:25385546). Interacts with MAPK8IP3/JIP3 (By similarity)

Synonyms

TRKC; gp145(trkC)

Documentation

User Guide for Antibodies (1077 KB)