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Nup93 Antibody (YA9610)

(Synonyms: NUP 93)
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Nup93 Antibody (YA9610) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Nup93.

For research use only. We do not sell to patients.
  • Host:

    Mouse

  • Isotype:

    IgG

  • Application:

    WB, ICC/IF, IF-Tissue, IHC-P, IP, ELISA

  • Reactivity :

    human, mouse, rat

  • Formulation:

    Supplied in PBS(pH7.4) containing 0.1% gelatin and < 0.1% sodium azide.

  • Conjugation:
    Non-conjugated
  • Nup93 Antibody (YA9610) Product Image
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Use of MCE Products

Applications

Application
WB Info
WB: Western Blot
ICC/IF Info
ICC/IF: Immunocytochemistry/
Immunofluorescence
IF-Tissue Info
IF-Tissue: Immunofluorescence-Tissue
IHC-P Info
IHC-P: Immunohistochemistry-Paraffin
IP Info
IP: Immunoprecipitation
ELISA Info
ELISA: Enzyme Linked Immunosorbent Assay
Dilution Ratio 1:500-1000 1:50-500 1:50-500 1:100-500 1-2μg per 100-500μg Total protein 1:50-3000

Product Details

Description

Nup93 Antibody (YA9610) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Nup93.

  • Host Mouse
  • Species Reactivity
    human, mouse, rat
  • Calculated Molecular Weight Predicted band size: 90 kDa
Immunogen

A synthesized peptide derived from human Nup93.

Sensitivity

Endogenous

Purification

Affinity purified

Conjugation

Non-conjugated

Modification

Unmodified

Isotype

IgG

Product Properties

  • Appearance

    Solution

  • Formulation

    Supplied in PBS(pH7.4) containing 0.1% gelatin and < 0.1% sodium azide.

  • Concentration

    Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration

  • Storage & Stability

    Stored at 2-8°C for 1 year, do not freeze.

  • Shipping

    Shipping with blue ice.

Background

  • Function

    Nup93 plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. May anchor nucleoporins, but not NUP153 and TPR, to the NPC. During renal development, regulates podocyte migration and proliferation through SMAD4 signaling[1][2].

  • Subcellular Localization

    Nucleus membrane; Nucleus, nuclear pore complex; Nucleus envelope

  • Isoforms & Post-Translational Modification

    Nup93 has 2 isoforms, Q8N1F7-1: amino acid length is 819, molecular weight is 93488 Da (predicted); Q8N1F7-2: amino acid length is 696, molecular weight is 79882 Da (predicted).

  • Subunit

    Part of the nuclear pore complex (NPC).

  • SwissProt ID

    Q8N1F7

  • Gene ID
    9688 [NCBI]
  • Synonyms

    NUP 93

References

[1]. Grandi P, et al. Nup93, a vertebrate homologue of yeast Nic96p, forms a complex with a novel 205-kDa protein and is required for correct nuclear pore assembly. Mol Biol Cell. 1997 Oct;8(10):2017-38. [Content Brief]

[2]. Braun DA, et al. Mutations in nuclear pore genes NUP93, NUP205 and XPO5 cause steroid-resistant nephrotic syndrome. Nat Genet. 2016 Apr;48(4):457-65. [Content Brief]

Nup93 Antibody (YA9610) Related Classifications

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100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
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