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Cat. No.: HY-P87771

Oct-4 Antibody (YA7456)

Oct-4 Antibody (YA7456) is a Rabbit-derived and non-conjugated IgG, Kappa monoclonal antibody, targeting to 45934.

For research use only. We do not sell to patients.

Formulation:
Supplied in PBS (pH7.4) containing 50% glycerol, 0.05% Proclin 300, 0.05%BSA

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Stock

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Applications

Application	IHC-P IHC-P: Immunohistochemistry-Paraffin	WB WB: Western Blot	ICC/IF ICC/IF: Immunocytochemistry/ Immunofluorescence	ELISA ELISA: Enzyme Linked Immunosorbent Assay	IP IP: Immunoprecipitation
Dilution Ratio	1:1000-1:5000	1:2000-1:10000	1:200-1:1000	1:5000-1:20000	1:50-1:200

Description

Oct-4 Antibody (YA7456) is a Rabbit-derived and non-conjugated IgG, Kappa monoclonal antibody, targeting to 45934.

Host Rabbit
Clonality Monoclonal,Recombinant
Species Reactivity
Human, Mouse
Observed Molecular Weight

Observed band size: 45 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
Calculated Molecular Weight Predicted band size: 39 kDa

Immunogen

The exact sequence is proprietary to MCE.

Sensitivity

Endogenous

Purification

Protein A affinity purified

Conjugation

Non-conjugated

Modification

Unmodified

Isotype

IgG,Kappa

Appearance

Liquid
Formulation

Supplied in PBS (pH7.4) containing 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping

Shipping with blue ice.

Function

2026-10-04 00:00:00 transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Forms a trimeric complex with SOX2 or SOX15 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency
Subcellular Localization

Cytoplasm,Nucleus
Expression

Tissue_Specificity: Expressed in developing brain. Highest levels found in specific cell layers of the cortex, the olfactory bulb, the hippocampus and the cerebellum. Low levels of expression in adult tissues
Induction: Transcriptional activity is positively regulated by PKM (PubMed:18191611). Upon cell differentiation, expression is repressed by NR6A1 (PubMed:26769970)
Isoforms & Post-Translational Modification

Q01860 has two isomers: Q01860-1: 38571 Da (predicted); Q01860-2: 30085 Da (predicted).
Sumoylation enhances the protein stability, DNA binding and transactivation activity丨Ubiquitinated; undergoes 'Lys-63'-linked polyubiquitination by WWP2 leading to proteasomal degradation丨ERK1/2-mediated phosphorylation at Ser-111 promotes nuclear exclusion and proteasomal degradation
Subunit

Interacts with PKM
SwissProt ID

Q01860