p57 Kip2 Antibody (YA2954)
(Synonyms: CDKN1C; KIP2; Cyclin-dependent kinase inhibitor 1C; Cyclin-dependent kinase inhibitor p57; p57Kip2)
Based on 1 Customer Validation
p57 Kip2 Antibody (YA2954) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to p57 Kip2.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IHC-P, ICC/IF, IP
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in rabbit IgG in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
IP
IP: Immunoprecipitation
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|---|---|---|---|---|
| Dilution Ratio | 1:1000-1:2000 | 1:100-1:200 | 1:50-1:200 | 1:50 |
Product Details
p57 Kip2 Antibody (YA2954) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to p57 Kip2.
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Host Rabbit
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Clonality Recombinant,Monoclonal
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Species ReactivityHuman, Mouse, Rat
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Observed Molecular WeightObserved band size: 57 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 32 kDa
Entrez Gene: 1028 Human ; 12577 Mouse ; 246060 Rat
SwissProt: P49918 Human ; P49919 Mouse ;
OMIM: 130650 Human
A synthesized peptide derived from human p57 Kip2 aa45-72.
Endogenous
Affinity Chromatography
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Liquid
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Formulation
Supplied in rabbit IgG in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
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Concentration
Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
p57 Kip2 is a Potent tight-binding inhibitor of several G1 cyclin/CDK complexes (cyclin E-CDK2, cyclin D2-CDK4, and cyclin A-CDK2) and, to lesser extent, of the mitotic cyclin B-CDC2. Negative regulator of cell proliferation. May play a role in maintenance of the non-proliferative state throughout life
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Subcellular Localization
Nucleus
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Expression
Tissue_specificity:This substance is expressed in the heart, brain, lungs, skeletal muscle, kidneys, pancreas, and testes. It is also expressed in the eyes. Higher concentrations are found in the placenta, while lower concentrations are found in the liver. -
Isoforms & Post-Translational Modification
P49918 has 2 isomers: P49918-1: 32177 Da (predicted); P49918-2: 31040 Da (predicted).
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Subunit
Interacts with PCNA
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SwissProt ID
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Synonyms
CDKN1C; KIP2; Cyclin-dependent kinase inhibitor 1C; Cyclin-dependent kinase inhibitor p57; p57Kip2
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Research Field
Cell Biology
Documentation
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