p57 Kip2 Antibody (YA5751)

Cat. No.: HY-P86059: Ficha de datos User Guide for Antibodies
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p57 Kip2 Antibody (YA5751) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to p57 Kip2.

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Tamaño		Stock
50 μL		Obtener un presupuesto
100 μL		Obtener un presupuesto

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Descripciòn

Descripciòn

p57 Kip2 Antibody (YA5751) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to p57 Kip2.

Host

Mouse

Clonality

Monoclonal

Peso molecular

Predicted band size: 50 kDa;

Observed band size: 57 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.

Species Reactivity

Human, Mouse, Rat

SwissProt ID

P49918

Gene ID

1028 [NCBI]

Immunogen

Synthesized peptide derived from human p57kip2 AA range: 200-316

Application &
Dilution Ratio

Application	Dilution Ratio
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:200-400
ELISA ELISA: Enzyme Linked Immunosorbent Assay	1:500-5000

Pureza	affinity chromatography.	Conjugation	Non-conjugated
Modification	Unmodified	Isotype	IgG2b

Appearance

Liquid

Formulation

Supplied in PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Envío

Shipping with blue ice.

Background

Function：Potent tight-binding inhibitor of several G1 cyclin/CDK complexes (cyclin E-CDK2, cyclin D2-CDK4, and cyclin A-CDK2) and, to lesser extent, of the mitotic cyclin B-CDC2. Negative regulator of cell proliferation. May play a role in maintenance of the non-proliferative state throughout life

Subcellular Localization：Nucleus

Expression：
Tissue_specificity:This substance is expressed in the heart, brain, lungs, skeletal muscle, kidneys, pancreas, and testes. It is also expressed in the eyes. Higher concentrations are found in the placenta, while lower concentrations are found in the liver.

Isoforms & Post-Translational Modification：P49918 has 2 isomers: P49918-1: 32177 Da (predicted); P49918-2: 31040 Da (predicted).

Subunit：Interacts with PCNA

Synonyms

Beckwith Wiedemann syndrome; BWCR; BWS; CDKI; CDKN 1C; CDKN1C; CDN1C_HUMAN; Cyclin dependent kinase inhibitor 1C; Cyclin dependent kinase inhibitor p57; Cyclin-dependent kinase inhibitor 1C; Cyclin-dependent kinase inhibitor p57; KIP 2; KIP2; p57; p57 Kip 2; p57KIP2; WBS

Documentación

User Guide for Antibodies (1077 KB)