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PCBP2 Antibody (YA7667)

PCBP2 Antibody (YA7667) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PCBP2.

For research use only. We do not sell to patients.

Host:
Rabbit
Isotype:
IgG
Application:
WB, IHC-P, IHC-F, IF-Tissue, ICC/IF, IP
Reactivity :
Human, Mouse, Rat

Formulation:
Supplied in 10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.

Conjugation:
Non-conjugated

Tamaño

Precio

Stock

Cantidad

Sample (0.1mg)

In-stock

(In Japan)

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Applications
Product Details
Product Properties
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- Formulation
- Storage & Stability
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Background
Documentación
Help & FAQs
Bioz

Applications

Application	WB WB: Western Blot	IHC-P IHC-P: Immunohistochemistry-Paraffin	IHC-F IHC-F: Immunohistochemistry-Frozen	IF-Tissue IF-Tissue: Immunofluorescence-Tissue	ICC/IF ICC/IF: Immunocytochemistry/ Immunofluorescence	IP IP: Immunoprecipitation
Dilution Ratio	1:500-2000	1:100-500	1:100-500	1:100-500	1:50-200	1:20-50

Product Details

Descripciòn

PCBP2 Antibody (YA7667) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PCBP2.

Host Rabbit
Clonality Recombinant
Species Reactivity
Human, Mouse, Rat
Observed Molecular Weight

Observed band size: 35,39 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
Calculated Molecular Weight Predicted band size: 39 kDa

Immunogen

A synthesized peptide derived from human PCBP2

Sensitivity

Endogenous

Purification

affinity purified by Protein A

Conjugation

Non-conjugated

Modification

Unmodified

Isotype

IgG

Product Properties

Appearance

Liquid
Formulation

Supplied in 10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Envío

Shipping with blue ice.

Background

Function

Single-stranded nucleic acid binding protein that binds preferentially to oligo dC (PubMed:12414943, PubMed:7607214). Major cellular poly(rC)-binding protein (PubMed:12414943). Also binds poly(rU) (PubMed:12414943). Acts as a negative regulator of antiviral signaling (PubMed:19881509, PubMed:35322803). Negatively regulates cellular antiviral responses mediated by MAVS signaling (PubMed:19881509). It acts as an adapter between MAVS and the E3 ubiquitin ligase ITCH, therefore triggering MAVS ubiquitination and degradation (PubMed:19881509). Negativeley regulates the cGAS-STING pathway via interaction with CGAS, preventing the formation of liquid-like droplets in which CGAS is activated (PubMed:35322803). Together with PCBP1, required for erythropoiesis, possibly by regulating mRNA splicing (By similarity)|(Microbial infection) In case of infection by poliovirus, binds to the viral internal ribosome entry site (IRES) and stimulates the IRES-mediated translation (PubMed:12414943, PubMed:24371074). Also plays a role in initiation of viral RNA replication in concert with the viral protein 3CD (PubMed:12414943)
Subcellular Localization

Nucleus,Cytoplasm
Expression

Tissue_Specificity: Detected in all tissues examined
Isoforms & Post-Translational Modification

Q15366 has 8 isomers: Q15366-1: 38580 Da (predicted); Q15366-2: 38651 Da (predicted); Q15366-3: 38222 Da (predicted); Q15366-4: 34917 Da (predicted); Q15366-5: 35347 Da (predicted); Q15366-6: 38151 Da (predicted); Q15366-7: 33497 Da (predicted); Q15366-8: 33926 Da (predicted).
Phosphorylated丨(Microbial infection) Proteolytically cleaved by picornavirus proteinase 3CD
Subunit

Identified in a mRNP complex, at least composed of DHX9, DDX3X, ELAVL1, HNRNPU, IGF2BP1, ILF3, PABPC1, PCBP2, PTBP2, STAU1, STAU2, SYNCRIP and YBX1 (PubMed:19029303)
SwissProt ID

Q15366