Periostin Antibody (YA6145)
Periostin Antibody (YA6145) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Periostin.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IHC-P, ICC/IF, IP, ELISA
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Reactivity :
Human
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Formulation:
Supplied in PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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WB
WB: Western Blot
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
ELISA
ELISA: Enzyme Linked Immunosorbent Assay
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IP
IP: Immunoprecipitation
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|---|---|---|---|---|---|
| Dilution Ratio | 1:200-1:1000 | 1:500-1:2000 | 1:200-1:1000 | 1:5000-1:20000 | 1:50-1:200 |
Product Details
Periostin Antibody (YA6145) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Periostin.
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Host Rabbit
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Clonality Monoclonal
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Species ReactivityHuman
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Observed Molecular WeightObserved band size: 93 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 93 kDa
Protein A
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
Periostin induces cell attachment and spreading and plays a role in cell adhesion. Enhances incorporation of BMP1 in the fibronectin matrix of connective tissues, and subsequent proteolytic activation of lysyl oxidase LOX[1].
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Subcellular Localization
Golgi apparatus; Secreted; Secreted, extracellular space, extracellular matrix
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Expression
Tissue_specificity:It is widely expressed, with the highest expression levels in the aorta, stomach, lower digestive tract, placenta, uterus, thyroid tissue, and breast. It is also expressed in the kidneys (PubMed: 21763681) and lungs (PubMed: 22079858) . Its expression is upregulated in ovarian epithelial tumors. It is not expressed in normal ovaries. It is also highly expressed around the tumor in lung cancer tissue, but not within the tumor itself. It is overexpressed in breast cancer. -
Isoforms & Post-Translational Modification
Q15063 has 10 isomers: Q15063-1: 93314 Da (predicted); Q15063-2: 87021 Da (predicted); Q15063-3: 87254 Da (predicted); Q15063-4: 83850 Da (predicted); Q15063-5: 90424 Da (predicted); Q15063-6: 83527 Da (predicted); Q15063-7: 80357 Da (predicted); Q15063-8: 90143 Da (predicted); Q15063-9: 90010 Da (predicted); Q15063-10: 86840 Da (predicted).
Gamma-carboxylation is controversial. Gamma-carboxyglutamated; gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation; this may be required for calcium binding (PubMed:18450759). According to a more recent report, does not contain vitamin K-dependent gamma-carboxyglutamate residues (PubMed:26273833) -
Subunit
Homodimer (PubMed:29754429). Interacts with BMP1 and fibronectin
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SwissProt ID
Documentation
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