Periostin Antibody (YA6145)

Cat. No.: HY-P86453: Ficha de datos User Guide for Antibodies
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Periostin Antibody (YA6145) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Periostin.

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Tamaño		Stock
50 μL		Obtener un presupuesto
100 μL		Obtener un presupuesto

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Descripciòn
Referencias

Descripciòn

Periostin Antibody (YA6145) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Periostin.

Host

Rabbit

Clonality

Monoclonal

Peso molecular

Predicted band size: 93 kDa;

Observed band size: 93 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.

Species Reactivity

Human

SwissProt ID

Q15063

Gene ID

10631 [NCBI]

Application &
Dilution Ratio

Application	Dilution Ratio
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:200-1:1000
WB WB: Western Blot	1:500-1:2000
ICC/IF ICC/IF: Immunocytochemistry/Immunofluorescence	1:200-1:1000
ELISA ELISA: Enzyme Linked Immunosorbent Assay	1:5000-1:20000
IP IP: Immunoprecipitation	1:50-1:200

Pureza	Protein A	Conjugation	Non-conjugated
Modification	Unmodified	Isotype	IgG

Appearance

Liquid

Formulation

Supplied in PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Envío

Shipping with blue ice.

Background

Function：Induces cell attachment and spreading and plays a role in cell adhesion (PubMed:12235007). Enhances incorporation of BMP1 in the fibronectin matrix of connective tissues, and subsequent proteolytic activation of lysyl oxidase LOX (By similarity)

Subcellular Localization：Golgi apparatus; Secreted; Secreted, extracellular space, extracellular matrix

Expression：
Tissue_specificity:It is widely expressed, with the highest expression levels in the aorta, stomach, lower digestive tract, placenta, uterus, thyroid tissue, and breast. It is also expressed in the kidneys (PubMed: 21763681) and lungs (PubMed: 22079858) . Its expression is upregulated in ovarian epithelial tumors. It is not expressed in normal ovaries. It is also highly expressed around the tumor in lung cancer tissue, but not within the tumor itself. It is overexpressed in breast cancer.

Isoforms & Post-Translational Modification：Q15063 has 10 isomers: Q15063-1: 93314 Da (predicted); Q15063-2: 87021 Da (predicted); Q15063-3: 87254 Da (predicted); Q15063-4: 83850 Da (predicted); Q15063-5: 90424 Da (predicted); Q15063-6: 83527 Da (predicted); Q15063-7: 80357 Da (predicted); Q15063-8: 90143 Da (predicted); Q15063-9: 90010 Da (predicted); Q15063-10: 86840 Da (predicted).
Gamma-carboxylation is controversial. Gamma-carboxyglutamated; gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation; this may be required for calcium binding (PubMed:18450759). According to a more recent report, does not contain vitamin K-dependent gamma-carboxyglutamate residues (PubMed:26273833)

Subunit：Homodimer (PubMed:29754429). Interacts with BMP1 and fibronectin

Documentación

User Guide for Antibodies (1077 KB)

Referencias

[1]. /biology-dictionary/hepg2-cell.html [Content Brief]