PSCA Antibody (YA5511)

Cat. No.: HY-P85819: Data Sheet User Guide for Antibodies
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PSCA Antibody (YA5511) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to PSCA.

For research use only. We do not sell to patients.

Size		Stock
50 μL		Get quote
100 μL		Get quote

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Documentation

Description

PSCA Antibody (YA5511) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to PSCA.

Host

Mouse

Clonality

Monoclonal

Molecular Weight

Predicted band size: 13 kDa;

Observed band size: 18 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.

Species Reactivity

Human

SwissProt ID

O43653

Gene ID

8000 [NCBI]

Immunogen

Synthesized peptide derived from human PSCA AA range: 1-100

Application &
Dilution Ratio

Application	Dilution Ratio
WB WB: Western Blot	1:500-2000
ICC/IF ICC/IF: Immunocytochemistry/Immunofluorescence	1:100-500
ELISA ELISA: Enzyme Linked Immunosorbent Assay	1:1000-5000

Purity	Protein G	Conjugation	Non-conjugated
Modification	Unmodified	Isotype	IgG2b

Appearance

Liquid

Formulation

Supplied in PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Background

Function：May be involved in the regulation of cell proliferation. Has a cell-proliferation inhibition activity in vitro; May act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro inhibits nicotine-induced signaling probably implicating alpha-3:beta-2- or alpha-7-containing nAChRs

Subcellular Localization：Cell membrane; Lipid-anchor, GPI-anchor

Expression：
Tissue_specificity:It is highly expressed in the prostate (basal epithelial cells, secretory epithelial cells, and neuroendocrine epithelial cells) . It is also found in the bladder (transitional epithelium) , placenta (trophoblast cells) , stomach (neuroendocrine cells) , colon (neuroendocrine cells) , and kidney (collecting ducts) . It is overexpressed in prostate cancer, and its expression is correlated with tumor stage, grade, and androgen-independent characteristics. It is highly expressed in bone metastases of prostate cancer. It is expressed in gastric epithelial cells, primarily in the gastric isthmus (protein level) . It is not detected in normal intestinal epithelium (protein level) . It is expressed in the cerebral cortex; its expression is significantly increased in the prefrontal cortex of Alzheimer's disease patients.

Induction:Down-regulated in gastric cancer cells

Subunit：Interacts with CHRNA4

Documentation

User Guide for Antibodies (1077 KB)