PSCA Antibody (YA5511)
PSCA Antibody (YA5511) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to PSCA.
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Host:
Mouse
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Isotype:
IgG2b
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Application:
WB, ICC/IF, ELISA
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Reactivity :
Human
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Formulation:
Supplied in PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
ELISA
ELISA: Enzyme Linked Immunosorbent Assay
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|---|---|---|---|
| Dilution Ratio | 1:500-2000 | 1:100-500 | 1:1000-5000 |
Product Details
PSCA Antibody (YA5511) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to PSCA.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman
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Observed Molecular WeightObserved band size: 18 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 13 kDa
Synthesized peptide derived from human PSCA AA range: 1-100
Protein G
Non-conjugated
Unmodified
IgG2b
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
PSCA may be involved in the regulation of cell proliferation. Has a cell-proliferation inhibition activity in vitro; May act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro inhibits nicotine-induced signaling probably implicating alpha-3:beta-2- or alpha-7-containing nAChRs
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Subcellular Localization
Cell membrane; Lipid-anchor, GPI-anchor
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Expression
Tissue_specificity:It is highly expressed in the prostate (basal epithelial cells, secretory epithelial cells, and neuroendocrine epithelial cells) . It is also found in the bladder (transitional epithelium) , placenta (trophoblast cells) , stomach (neuroendocrine cells) , colon (neuroendocrine cells) , and kidney (collecting ducts) . It is overexpressed in prostate cancer, and its expression is correlated with tumor stage, grade, and androgen-independent characteristics. It is highly expressed in bone metastases of prostate cancer. It is expressed in gastric epithelial cells, primarily in the gastric isthmus (protein level) . It is not detected in normal intestinal epithelium (protein level) . It is expressed in the cerebral cortex; its expression is significantly increased in the prefrontal cortex of Alzheimer's disease patients.
Induction:Down-regulated in gastric cancer cells -
Subunit
Interacts with CHRNA4
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SwissProt ID
Documentation
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