RAB9A Antibody (YA1800)(PBS only)

Cat. No.: HY-P82055A: Data Sheet User Guide for Antibodies
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RAB9A Antibody (YA1800) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to RAB9A.

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사이즈		재고
50 μL		견적 받기
100 μL		견적 받기

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
제품 설명

제품 설명

RAB9A Antibody (YA1800) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to RAB9A.

Host

Rabbit

분자량

Predicted band size: 23 kDa;

Observed band size: 23 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.

Species Reactivity

Human, Mouse

SwissProt ID

P51151

Gene ID

9367 [NCBI]

Immunogen

A synthetic peptide of human Rab9

Application &
Dilution Ratio

Application	Dilution Ratio
WB WB: Western Blot	1:500-1:1000
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:50-1:100

Purity	Affinity Purified	Conjugation	Non-conjugated
Isotype	IgG

Appearance

Liquid

Formulation

Supplied in PBS, pH 7.4.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

선적

Shipping with blue ice.

Background

Function：The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). RAB9A is involved in the transport of proteins between the endosomes and the trans-Golgi network (TGN) (PubMed:34793709). Specifically uses NDE1/NDEL1 as an effector to interact with the dynein motor complex in order to control retrograde trafficking of RAB9-associated late endosomes to the TGN (PubMed:34793709). Involved in the recruitment of SGSM2 to melanosomes and is required for the proper trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes (By similarity)

Subcellular Localization：Cell membrane; Lipid-anchor; Cytoplasmic side; Endoplasmic reticulum membrane; Golgi apparatus membrane; Late endosome; Cytoplasmic vesicle, phagosome membrane; Lipid-anchor; Cytoplasmic side; Cytoplasmic vesicle, phagosome; Cytoplasmic vesicle membrane; Melanosome

Subunit：Interacts (preferentially in its GTP-bound form) with GCC2 (via its GRIP domain) (PubMed:16885419, PubMed:18243103). Interacts (GTP-bound form) with SGSM1; the GDP-bound form has much lower affinity for SGSM1 (PubMed:22637480). Interacts with SGSM2 (PubMed:21808068). The GTP-bound form but not the GDP-bound form interacts with HPS4 and BLOC-3 complex (heterodimer of HPS1 and HPS4) but does not interact with HPS1 alone (PubMed:20048159). Interacts (GTP-bound form) with NDE1; two RAB9A-GTP molecules lie on the opposite sides of the NDE1 homodimer; the interaction leads to RAB9A-dynein motor tethering (PubMed:34793709). Interacts (GTP-bound form) with NDEL1 (PubMed:34793709)

Research Field

Tags & Cell Markers

Synonyms

RAB9A; DmRab9; Ras related protein Rab 9A

각종 서류

User Guide for Antibodies (1077 KB)