RAB9A - RAB9A, member RAS oncogene family Gene

Also Known as RAB9

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9367

About RAB9A

Cytogenetic location: Xp22.2 Genomic coordinates (GRCh38): X:13,689,128-13,710,504 (from NCBI)

This gene has 3 transcripts (splice variants), 268 orthologues and 68 paralogues. Ubiquitous expression in adrenal (RPKM 21.5), bone marrow (RPKM 11.2) and 25 other tissues.

Summary

Enables GDP binding activity; GTP binding activity; and GTPase activity. Involved in negative regulation by host of symbiont catalytic activity; positive regulation of exocytosis; and regulation of protein localization. Located in late endosome; lysosome; and phagocytic vesicle. [provided by Alliance of Genome Resources, Apr 2022]

RAB9A Products (2)

mRNA Protein Name
NM_001195328.2 NP_001182257.1 ras-related protein Rab-9A
NM_004251.5 NP_004242.1 ras-related protein Rab-9A

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables GDP binding IDA
IDA: Inferred from direct assay
15263003 GOA
enables GTP binding IDA
IDA: Inferred from direct assay
15263003 GOA
enables GTPase activity IDA
IDA: Inferred from direct assay
15263003 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
15471887 GOA
Biological Process GO Annotation Evidence Verweise Source
involved in negative regulation by host of symbiont catalytic activity IMP
IMP: Inferred from mutant phenotype
18787122 GOA
involved in positive regulation of exocytosis IMP
IMP: Inferred from mutant phenotype
19966785 GOA
involved in regulation of protein localization IMP
IMP: Inferred from mutant phenotype
18787122 GOA
Cellular Component GO Annotation Evidence Verweise Source
located in late endosome IDA
IDA: Inferred from direct assay
15078902 GOA
located in lysosome IDA
IDA: Inferred from direct assay
15078902 GOA
located in phagocytic vesicle IDA
IDA: Inferred from direct assay
21255211 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RAB9A Protein Structure

Ras

Ras: Ras family (9 - 173)

  • 0
  • 100
  • 201 a.a.
Protein Preferred Names Protein Names

ras-related protein Rab-9A

  • RAB9, member RAS oncogene family

RAB9A Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
RAB9A P51151 NISCH Homo sapiens Q9Y2I1
IF
23386062
Intra
RAB9A P51151 NISCH Homo sapiens Q9Y2I1
BioID
29568061
Intra
RAB9A P51151 PLEKHM2 Homo sapiens Q8IWE5
Pull Down
18787122
Cross: Cross-species interaction Intra: Intraspecies interaction

RAB9A Antibodies

Art. -Nr. Produktname Anwendung Reactivity
HY-P82055 RAB9A Antibody (YA1800) WB, IHC-P Human, Mouse
HY-P82055A RAB9A Antibody (YA1800)(PBS only) WB, IHC-P Human, Mouse

Related Diseases

Diseases Alias
Warburg Micro Syndrome 1

  • Warburg Micro Syndrome

  • Micro Syndrome

  • Warbm

  • WARBM1

  • Warburg Sjo Fledelius Syndrome

  • Warburg-Sjo-Fledelius Syndrome

  • Micro Syndrome 1

  • Microcephaly, Microcornea, Congenital Cataract, Intellectual Disability, Optic Atrophy And Hypogenitalism
Simpson-Golabi-Behmel Syndrome, Type 2

  • Simpson-Golabi-Behmel Syndrome Type 2

  • SGBS2

  • Simpson-Golabi-Behmel Syndrome 2
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS11580 RAB9A Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus RAB9A RGD RGD:619740
Mus musculus RAB9A MGD MGI:1890695
Canis familiaris RAB9A VGNC VGNC:45297
Bos taurus RAB9A VGNC VGNC:33664
Macaca mulatta RAB9A VGNC VGNC:81551
Felis catus RAB9A VGNC VGNC:97596
Others RAB9A NCBI