Renalase Antibody (YA2473)
(Synonyms: MAO C; mMAO C; Renalase; RNLS)
Based on 1 Customer Validation
Renalase Antibody (YA2473) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Renalase.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IHC-P
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in rabbit IgG in 10mM PBS, pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|---|
| Dilution Ratio | 1:1000-1:2000 | 1:50-1:100 |
Product Details
Renalase Antibody (YA2473) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Renalase.
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Host Rabbit
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Clonality Recombinant,Monoclonal
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Species ReactivityHuman, Mouse, Rat
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Observed Molecular WeightObserved band size: 42 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 38 kDa
Entrez Gene: 55328 Human ; 361751 Rat
SwissProt: Q5VYX0 Human ; A7RDN6 Mouse ; Q5U2W9 Rat
OMIM: 609360 Human
A synthesized peptide derived from human Renalase aa50-100/342.
Endogenous
Affinity Purified
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in rabbit IgG in 10mM PBS, pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.
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Concentration
Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
Renalase catalyzes the oxidation of the less abundant 1,2-dihydro-beta-NAD(P) and 1,6-dihydro-beta-NAD(P) to form beta-NAD(P)(+). The enzyme hormone is secreted by the kidney, and circulates in blood and modulates cardiac function and systemic blood pressure. Lowers blood pressure in vivo by decreasing cardiac contractility and heart rate and preventing a compensatory increase in peripheral vascular tone, suggesting a causal link to the increased plasma catecholamine and heightened cardiovascular risk. High concentrations of catecholamines activate plasma renalase and promotes its secretion and synthesis
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Subcellular Localization
Secreted
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Expression
Tissue_specificity:Secreted into the blood by the kidney. Highly expressed in the kidney, expressed at lower level in heart, skeletal muscle and small intestine. Its plasma concentration is markedly reduced with end-stage renal disease, as compared with healthy subjects -
Isoforms & Post-Translational Modification
Renalase has 2 isomers: Q5VYX0-1: 37847 Da (predicted); Q5VYX0-2: 34949 Da (predicted).
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SwissProt ID
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Synonyms
MAO C; mMAO C; Renalase; RNLS
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Research Field
Neuroscience
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