RNLS - renalase, FAD dependent amine oxidase Gene

Also Known as C10orf59; RENALASE

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 55328

About RNLS

Cytogenetic location: 10q23.31 Genomic coordinates (GRCh38): 10:88,171,523-88,583,318 (from NCBI)

This gene has 5 transcripts (splice variants), 208 orthologues and is associated with 1 phenotype. Low expression observed in reference dataset.

Summary

Renalase is a flavin adenine dinucleotide-dependent amine oxidase that is secreted into the blood from the kidney (Xu et al., 2005 [PubMed 15841207]).[supplied by OMIM, Mar 2008]

RNLS Products (2)

mRNA	Protein	Name
NM_001031709.3	NP_001026879.2	renalase isoform 1 precursor
NM_018363.4	NP_060833.1	renalase isoform 2 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables NADH binding	IDA IDA: Inferred from direct assay	25531177	GOA
enables epinephrine binding	IDA IDA: Inferred from direct assay	23964689	GOA
enables monoamine oxidase activity	IMP IMP: Inferred from mutant phenotype	15841207	GOA
enables oxidoreductase activity, acting on NAD(P)H	IDA IDA: Inferred from direct assay	23964689	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25906147	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of blood pressure	IDA IDA: Inferred from direct assay	15841207	GOA
involved in negative regulation of heart rate	IDA IDA: Inferred from direct assay	15841207	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in extracellular region	IDA IDA: Inferred from direct assay	15841207	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RNLS Protein Structure

NAD_binding_8

Amino_oxidase

0
100
200
300
342 a.a.

Protein Preferred Names	Protein Names
renalase	MAO-C

RNLS Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	RNLS	Q5VYX0	ATP2B4	Homo sapiens	P23634	Confocal	25906147
Intra	RNLS	Q5VYX0	ATP2B4	Homo sapiens	P23634	Anti Bait CoIP	25906147

Cross: Cross-species interaction Intra: Intraspecies interaction

RNLS Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82728	Renalase Antibody (YA2473)	WB, IHC-P	Human, Mouse, Rat

Related Diseases

Diseases	Alias
End Stage Renal Disease	End Stage Renal Failure End-Stage Kidney Disease Kidney Failure, Chronic Chronic Kidney Disease Stage 5
Retinitis Pigmentosa 57	RP57 Pde6g-Related Retinitis Pigmentosa Retinitis Pigmentosa, Type 57
Kidney Disease	Renal Failure Kidney Failure Kidney Diseases Nephropathy Abnormality Of The Kidney Impaired Renal Function Disease Renal Anomaly Kidney Dysfunction Renal Disease Nephropathies Renal Failure Adverse Event Abnormal Renal Function
Chronic Kidney Disease	Chronic Renal Disease Chronic Kidney Failure Ckd Chronic Renal Failure Kidney Failure, Chronic Chronic Renal Failure Syndrome Crf Renal Failure - Chronic Renal Failure Chronic Chronic Kidney Diseases Chronic Kidney Disease Stage 5 Ckd - [Chronic Kidney Disease] Crf - [Chronic Renal Failure] Chronic Kidney Impairment Chronic Renal Impairment Chronic Kidney Shutdown Chronic Hypoxic Kidney Failure Chronic Kidney Collapse Chronic Renal Insufficiency Chronic Kidney Toxaemia Chronic Kidney Hypofunction Chronic Renal Suppression Chronic Renal Failure, Stage 5 Ckd - [Chronic Kidney Disease] Stage 5 End Stage Kidney Failure End Stage Renal Failure End Stage Kidney Disease End Stage Renal Disease End Stage Chronic Renal Failure Esrf - [End Stage Renal Failure] Esrd - [End Stage Renal Diseases] Egfr - [Estimated Glomerular Filtration Rate] < 15 Ml/Min/1.73m²
Chromosome 5q Deletion Syndrome	5q- Syndrome Mar Myelodysplastic Syndrome Associated With Isolated Del Chromosome Abnormality Macrocytic Anemia, Refractory, Due To 5q Deletion, Somatic 5q Deletion Syndrome 5q Minus Syndrome Refractory Macrocytic Anemia Due To 5q Deletion Myelodysplastic Syndrome With Isolated Del Macrocytic Anemia, Refractory, Due To 5q Deletion 5q- Syndrome, Refractory Macrocytic Anemia Due To 5q Deletion 5q Syndrome Chromosome 5q Deletion Myelodysplastic Syndrome With 5q Deletion Myelodysplastic Syndrome With 5q Deletion Syndrome Anemia, Macrocytic, Refractory, Due To 5q Deletion, Somatic 5q-Syndrome Chromosome 5, Trisomy 5q Loss Of Chromosome 5q 5 Q- Syndrome
Hypertension, Essential	Essential Hypertension Hypertension High Blood Pressure Hypertension, Essential, Susceptibility To Hypertensive Disease Primary Hypertension EHT Hypertension, Salt-Sensitive Essential, Susceptibility To Hyperpiesia Idiopathic Hypertension Hypertensive Disorder Hypertension, Essential, Susceptibility To, 3 Hypertension, Essential 3 Hypertension, Essential, Salt-Sensitive Hypertension, Essential, Susceptibility To, 6 Hypertension, Essential 6 Hypertension, Salt-Sensitive Essential Hypertension, Susceptibility To Hypertension, Essential, Susceptibility To, 4 Hypertension, Essential 4 Hypertension, Essential, Susceptibility To, 2 Hypertension, Essential 2 Hypertension, Essential, Susceptibility To, 1 Hypertension, Essential 1 Hypertension, Essential, Susceptibility To, 5 Hypertension, Essential 5 Htn Vascular Hypertensive Disorder Systemic Primary Arterial Hypertension Hbp - [High Blood Pressure] Systemic Arterial Hypertensive Disorder Elevated Blood Pressure Arterial Hypertension Nos Hypertension Nos Benign Hypertension Systemic Arterial Hypertension Systemic Hypertension Artery Htn Benign Htn Vascular Htn Vascular Hypertension Cholesterol Hypertension Cholesterol Htn Idiopathic Htn Malignant Hypertension Malignant Htn Raised Blood Pressure Cardiovascular Hypertension Primary Htn - [Hypertension] High Arterial Tension High Blood Pressure Disorder Ht - [Hypertension] Htn - [Hypertension] Hypertensive Vascular Disease Hypertensive Vascular Degeneration
Bruxism	Sleep Bruxism Sleep-Related Bruxism Bruxism - Teeth Grinding Grinding Teeth Sleep Related Bruxism Teeth Grinding Sleep Related Teeth Grinding
Cardiovascular System Disease	Abnormality Of The Cardiovascular System Cardiovascular Disease Disease Of Subdivision Of Hemolymphoid System Disorder Of Cardiovascular System Cardiovascular Diseases

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12101	RNLS Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18635	Rnls Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25120	Rnls Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	RNLS	VGNC	VGNC:82226
Mus musculus	RNLS	MGD	MGI:1915045
Canis familiaris	RNLS	VGNC	VGNC:45681
Bos taurus	RNLS	VGNC	VGNC:106901
Rattus norvegicus	RNLS	RGD	RGD:1309804
Others	RNLS	NCBI