ROR1 Antibody (YA4162)

Cat. No.: HY-P84465: Ficha de datos User Guide for Antibodies
FAQs
Technical Support

ROR1 Antibody (YA4162) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to ROR1.

Para uso exclusivo en investigación. No vendemos a pacientes.

Tamaño	Stock	Cantidad
20 μL	Obtener un presupuesto 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
50 μL	Obtener un presupuesto 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
100 μL	Obtener un presupuesto 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
250 μL	Obtener un presupuesto

Synthetic products have potential research and development risk.

or Consulta para venta a granel

* Seleccione Cantidad antes de agregar artículos.

WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Descripciòn

Descripciòn

ROR1 Antibody (YA4162) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to ROR1.

Host

Mouse

Clonality

Monoclonal Antibody

Peso molecular

Predicted band size: 101 kDa;

Observed band size: 50-70 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.

Species Reactivity

Human

SwissProt ID

Q01973

Gene ID

4919 [NCBI]

Immunogen

Recombinant extracellular fragment of human ROR1 (aa30-406) fused with hIgGFc tag, expressed in HEK293 cells

Application &
Dilution Ratio

Application	Dilution Ratio
ICC/IF ICC/IF: Immunocytochemistry/Immunofluorescence	1:200-1:1000
ELISA ELISA: Enzyme Linked Immunosorbent Assay	1:10000

Pureza	affinity purified.	Conjugation	Non-conjugated
Modification	Unmodified	Isotype	IgG1

Appearance

Liquid

Formulation

Supplied in PBS with 0.05% sodium azide.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Envío

Shipping with blue ice.

Background

Function：Has very low kinase activity in vitro and is unlikely to function as a tyrosine kinase in vivo (PubMed:25029443). Receptor for ligand WNT5A which activate downstream NFkB signaling pathway and may result in the inhibition of WNT3A-mediated signaling (PubMed:25029443, PubMed:27162350). In inner ear, crucial for spiral ganglion neurons to innervate auditory hair cells (PubMed:27162350). Via IGFBP5 ligand, forms a complex with ERBB2 to enhance CREB oncogenic signaling (PubMed:36949068)

Subcellular Localization：Membrane; Single-pass type I membrane protein; Cell projection, axon

Expression：
Tissue_specificity:This gene is expressed strongly in the human heart, lungs, and kidneys, but weakly in the central nervous system. The short subtype is expressed strongly in the human central nervous system and in a variety of human cancers, including cancers originating from the neuroectoderm of the central or peripheral nervous system.

Isoforms & Post-Translational Modification：Q01973 has 3 isomers: Q01973-1: 104283 Da (predicted); Q01973-2: 42833 Da (predicted); Q01973-3: 43826 Da (predicted).

Subunit：Interacts with ERBB2 and IGFBP5

Synonyms

ROR1

Documentación

User Guide for Antibodies (1077 KB)