ROR1 Antibody (YA4162)
(Synonyms: ROR1)ROR1 Antibody (YA4162) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to ROR1.
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Host:
Mouse
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Isotype:
IgG1
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Application:
WB, ICC/IF, ELISA
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Reactivity :
Human
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Formulation:
Supplied in PBS with 0.05% sodium azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
ELISA
ELISA: Enzyme Linked Immunosorbent Assay
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|---|---|---|
| Dilution Ratio | 1:200-1:1000 | 1:10000 |
Product Details
ROR1 Antibody (YA4162) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to ROR1.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman
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Observed Molecular WeightObserved band size: 50-70 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 101 kDa
Recombinant extracellular fragment of human ROR1 (aa30-406) fused with hIgGFc tag, expressed in HEK293 cells
affinity purified.
Non-conjugated
Unmodified
IgG1
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS with 0.05% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
ROR1 is a Has very low kinase activity in vitro and is unlikely to function as a tyrosine kinase in vivo. Receptor for ligand WNT5A which activate downstream NFkB signaling pathway and may result in the inhibition of WNT3A-mediated signaling. In inner ear, crucial for spiral ganglion neurons to innervate auditory hair cells. Via IGFBP5 ligand, forms a complex with ERBB2 to enhance CREB oncogenic signaling[1][2][3].
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Subcellular Localization
Membrane; Single-pass type I membrane protein; Cell projection, axon
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Expression
Tissue_specificity:This gene is expressed strongly in the human heart, lungs, and kidneys, but weakly in the central nervous system. The short subtype is expressed strongly in the human central nervous system and in a variety of human cancers, including cancers originating from the neuroectoderm of the central or peripheral nervous system. -
Isoforms & Post-Translational Modification
Q01973 has 3 isomers: Q01973-1: 104283 Da (predicted); Q01973-2: 42833 Da (predicted); Q01973-3: 43826 Da (predicted).
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Subunit
Interacts with ERBB2 and IGFBP5
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SwissProt ID
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Synonyms
ROR1
Documentation
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