Rtn-3 Antibody (YA5050)
(Synonyms: RTN3; ASYIP; NSPL2; Reticulon-3; Neuroendocrine-specific protein-like 2; NSP-like protein 2; Neuroendocrine-specific protein-like II; NSP-like protein II; NSPLII)Rtn-3 Antibody (YA5050) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Rtn-3.
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Host:
Mouse
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Isotype:
IgG2a
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Application:
IHC-P, ELISA
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Reactivity :
Human
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Formulation:
Supplied in PBSwith0.05%sodiumazide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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ELISA
ELISA: Enzyme Linked Immunosorbent Assay
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|---|---|---|
| Dilution Ratio | 1:200-1:1000 | 1:10000 |
Product Details
Rtn-3 Antibody (YA5050) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Rtn-3.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman
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Calculated Molecular Weight Predicted band size: 113kDa;
Purified recombinant fragment of RTN3 expressed in E.Coli. The exact sequence is proprietary to MCE.
Endogenous
affinity purified
Non-conjugated
Unmodified
IgG2a
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBSwith0.05%sodiumazide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
Rtn-3 may be involved in membrane trafficking in the early secretory pathway. Inhibits BACE1 activity and amyloid precursor protein processing. May induce caspase-8 cascade and apoptosis. May favor BCL2 translocation to the mitochondria upon endoplasmic reticulum stress. Induces the formation of endoplasmic reticulum tubules. Also acts as an inflammation-resolving regulator by interacting with both TRIM25 and RIGI, subsequently impairing RIGI 'Lys-63'-linked polyubiquitination leading to IRF3 and NF-kappa-B inhibition; (Microbial infection) Plays a positive role in viral replication and pathogenesis of enteroviruses[1].
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Subcellular Localization
Endoplasmic reticulum membrane; Multi-pass membrane protein; Golgi apparatus membrane; Multi-pass membrane protein
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Expression
Tissue_specificity:Isomer 3 is widely expressed, with the highest concentration in the brain, particularly enriched in the cell bodies of gray matter neurons (protein level) . Its concentration in the macula is three times that in the peripheral retina. Isomer 1 is highly expressed in the brain and poorly expressed in skeletal muscle. Isomer 2 is found only in melanoma.
Induction:By endoplasmic reticulum stress (at protein level) (PubMed:17191123) . Up-regulated and self-aggregates upon RNA viral infection (PubMed:34313226) -
Isoforms & Post-Translational Modification
O95197 has 7 isomers: O95197-1: 112611 Da (predicted); O95197-2: 110652 Da (predicted); O95197-3: 25609 Da (predicted); O95197-4: 27568 Da (predicted); O95197-5: 26452 Da (predicted); O95197-6: 23489 Da (predicted); O95197-7: 100824 Da (predicted).
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Subunit
Homodimer. Interacts with ATL1 (By similarity). Interacts with RTN4. Isoform 3 interacts with BACE1, BACE2, BCL2 and FADD. Interacts with ATL2. Interacts with TMEM33 (By similarity). Interacts with ZFYVE27 and with KIF5A in a ZFYVE27-dependent manner (PubMed:21976701). Interacts with RIGI (PubMed:34313226). Interacts with TRIM25 (PubMed:34313226)
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SwissProt ID
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Synonyms
RTN3; ASYIP; NSPL2; Reticulon-3; Neuroendocrine-specific protein-like 2; NSP-like protein 2; Neuroendocrine-specific protein-like II; NSP-like protein II; NSPLII
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