SARS-E2 Antibody (YA5056)
SARS-E2 Antibody (YA5056) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to SARS-E2.
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Host:
Mouse
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Application:
WB, ELISA
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Reactivity :
Virus
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Formulation:
Supplied in Subclonal supernatant.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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ELISA
ELISA: Enzyme Linked Immunosorbent Assay
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|---|---|---|
| Dilution Ratio | 1:500-1:2000 | 1:10000 |
Product Details
SARS-E2 Antibody (YA5056) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to SARS-E2.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityVirus
Purified recombinant fragment of SARS-E2 glycoprotein precursor expressed in E. Coli.
affinity purified.
Non-conjugated
Unmodified
Product Properties
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Appearance
Liquid
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Formulation
Supplied in Subclonal supernatant.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
SARS-E2 plays a central role in virus morphogenesis and assembly. Acts as a viroporin and self-assembles in host membranes forming pentameric protein-lipid pores that allow ion transport. Also plays a role in the induction of apoptosis. Regulates the localization of S protein at cis-Golgi, the place of virus budding. May act by slowing down the cell secretory pathway. May interfere with tight-junction stability by interacting with host MPP5. This would result in disruption of epithelial barriers, thereby amplifying inflammatory processes[1][2].
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Subcellular Localization
Host Golgi apparatus membrane; Single-pass type III membrane protein
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Subunit
Homopentamer (PubMed:33177698). Interacts via C-terminus PDM domain with PDZ domain-containing host proteins such as PALS1/MPP5 (PubMed:32891874, PubMed:35283834), TJP1/ZO1 (PubMed:35283834), LNX2 (PubMed:35283834), PARD3 (PubMed:35283834), and AFDN/MLLT4 (PubMed:35283834).
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SwissProt ID
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