SLP2 Antibody (YA1720)(PBS only)
(Synonyms: stomatin like 2; SLP-2; HSPC108)SLP2 Antibody (YA1720) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SLP2.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, ICC/IF, IP
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in PBS, pH 7.4.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
IP
IP: Immunoprecipitation
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|---|---|---|---|
| Dilution Ratio | 1:500-1:1000 | 1:50-1:200 | 1:20 |
Product Details
SLP2 Antibody (YA1720) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SLP2.
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Host Rabbit
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Species ReactivityHuman, Mouse, Rat
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Observed Molecular WeightObserved band size: 39 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 39 kDa
A synthetic peptide of human STOML2
Affinity Purified
Non-conjugated
IgG
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS, pH 7.4.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
SLP2 is a Mitochondrial protein that probably regulates the biogenesis and the activity of mitochondria. Stimulates cardiolipin biosynthesis, binds cardiolipin-enriched membranes where it recruits and stabilizes some proteins including prohibitin and may therefore act in the organization of functional microdomains in mitochondrial membranes. Through regulation of the mitochondrial function may play a role into several biological processes including cell migration, cell proliferation, T-cell activation, calcium homeostasis and cellular response to stress. May play a role in calcium homeostasis through negative regulation of calcium efflux from mitochondria. Required for mitochondrial hyperfusion a pro-survival cellular response to stress which results in increased ATP production by mitochondria. May also regulate the organization of functional domains at the plasma membrane and play a role in T-cell activation through association with the T-cell receptor signaling complex and its regulation
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Subcellular Localization
Cell membrane; Peripheral membrane protein; Mitochondrion; Mitochondrion inner membrane; Lipid-anchor; Mitochondrion intermembrane space; Membrane raft; Cytoplasm, cytoskeleton
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Expression
Tissue_specificity:Ubiquitously expressed at low levels. Expressed in lymphoid tissues (at protein level)
Induction:Up-regulated in activated B- and T-cells and upon mitochondrial stress by chloramphenicol -
Isoforms & Post-Translational Modification
Q9UJZ1 has 2 isomers: Q9UJZ1-1: 38534 Da (predicted); Q9UJZ1-2: 33337 Da (predicted).
Hyperphosphorylated at Ser-17 in some patients with monoclonal gammopathy of undetermined significance (MGUS), multiple myeloma (MM) and Waldenstrom macroglobulinemia due to impaired dephosphorylation by PP2A -
Subunit
Forms homooligomers. Interacts with MFN2; may form heterooligomers.
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SwissProt ID
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Synonyms
stomatin like 2; SLP-2; HSPC108
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Research Field
Cancer
Documentation
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