SLP2 Antibody (YA1720)(PBS only)

Cat. No.: HY-P81975A: Data Sheet User Guide for Antibodies
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SLP2 Antibody (YA1720) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SLP2.

For research use only. We do not sell to patients.

Size		Stock
50 μL		Get quote
100 μL		Get quote

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Documentation

Description

SLP2 Antibody (YA1720) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SLP2.

Host

Rabbit

Molecular Weight

Predicted band size: 39 kDa;

Observed band size: 39 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.

Species Reactivity

Human, Mouse, Rat

SwissProt ID

Q9UJZ1

Gene ID

30968 [NCBI]

Immunogen

A synthetic peptide of human STOML2

Application &
Dilution Ratio

Application	Dilution Ratio
WB WB: Western Blot	1:500-1:1000
ICC/IF ICC/IF: Immunocytochemistry/Immunofluorescence	1:50-1:200
IP IP: Immunoprecipitation	1:20

Purity	Affinity Purified	Conjugation	Non-conjugated
Isotype	IgG

Appearance

Liquid

Formulation

Supplied in PBS, pH 7.4.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Background

Function：Mitochondrial protein that probably regulates the biogenesis and the activity of mitochondria. Stimulates cardiolipin biosynthesis, binds cardiolipin-enriched membranes where it recruits and stabilizes some proteins including prohibitin and may therefore act in the organization of functional microdomains in mitochondrial membranes. Through regulation of the mitochondrial function may play a role into several biological processes including cell migration, cell proliferation, T-cell activation, calcium homeostasis and cellular response to stress. May play a role in calcium homeostasis through negative regulation of calcium efflux from mitochondria. Required for mitochondrial hyperfusion a pro-survival cellular response to stress which results in increased ATP production by mitochondria. May also regulate the organization of functional domains at the plasma membrane and play a role in T-cell activation through association with the T-cell receptor signaling complex and its regulation

Subcellular Localization：Cell membrane; Peripheral membrane protein; Mitochondrion; Mitochondrion inner membrane; Lipid-anchor; Mitochondrion intermembrane space; Membrane raft; Cytoplasm, cytoskeleton

Expression：
Tissue_specificity:Ubiquitously expressed at low levels. Expressed in lymphoid tissues (at protein level)

Induction:Up-regulated in activated B- and T-cells and upon mitochondrial stress by chloramphenicol

Isoforms & Post-Translational Modification：Q9UJZ1 has 2 isomers: Q9UJZ1-1: 38534 Da (predicted); Q9UJZ1-2: 33337 Da (predicted).
Hyperphosphorylated at Ser-17 in some patients with monoclonal gammopathy of undetermined significance (MGUS), multiple myeloma (MM) and Waldenstrom macroglobulinemia due to impaired dephosphorylation by PP2A

Subunit：Forms homooligomers. Interacts with MFN2; may form heterooligomers.

Research Field

Cancer

Synonyms

stomatin like 2; SLP-2; HSPC108

Documentation

User Guide for Antibodies (1077 KB)