SYT4 Antibody (YA8407)

Cat. No.: HY-P88723: Data Sheet User Guide for Antibodies
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SYT4 Antibody (YA8407) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to SYT4.

For research use only. We do not sell to patients.

Size		Stock
50 μL		Get quote
100 μL		Get quote

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Documentation

Description

SYT4 Antibody (YA8407) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to SYT4.

Host

Mouse

Clonality

Monoclonal

Molecular Weight

Predicted band size: 47.8 kDa

Species Reactivity

Human, Mouse, Rat

SwissProt ID

Q9H2B2

Immunogen

Full length human recombinant protein of human SYT4 produced in HEK293T cell.

Application &
Dilution Ratio

Application	Dilution Ratio
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:100-200
ICC/IF ICC/IF: Immunocytochemistry/Immunofluorescence	1:100-250

Sensitivity	Endogenous	Purity	Affinity purified
Conjugation	Non-conjugated	Modification	Unmodified
Isotype	IgG1

Appearance

Liquid

Formulation

Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Background

Function：Synaptotagmin family member which does not bind Ca(2+) (By similarity) (PubMed:23999003). Involved in neuronal dense core vesicles (DCVs) mobility through its interaction with KIF1A. Upon increased neuronal activity, phosphorylation by MAPK8/JNK1 destabilizes the interaction with KIF1A and captures DCVs to synapses (By similarity). Plays a role in dendrite formation by melanocytes (PubMed:23999003)

Subcellular Localization：Cytoplasmic vesicle, secretory vesicle, neuronal dense core vesicle membrane

Expression：
Tissue_Specificity: Expressed in melanocytes (PubMed:23999003). Expressed in brain. Within brain, expression is highest in hippocampus, with substantial levels also detected in amygdala and thalamus (PubMed:23999003)

Isoforms & Post-Translational Modification：Q9H2B2 has two isomers: Q9H2B2-1: 47958 Da (predicted); Q9H2B2-2: 46064 Da (predicted).
Phosphorylation at Ser-135 by MAPK8/JNK1 reduces interaction with KIF1A and neuronal dense core vesicles mobility

Subunit：Interacts with KIF1A; the interaction increases in presence of calcium and decreases when SYT4 is phosphorylated at Ser-135

Synonyms

HsT1192

Documentation

User Guide for Antibodies (1077 KB)