SYT4 Antibody (YA8407)
(Synonyms: HsT1192)SYT4 Antibody (YA8407) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to SYT4.
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Host:
Mouse
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Isotype:
IgG1
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Application:
IHC-P, ICC/IF
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Reactivity :
Human, Mouse, Rat
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Formulation:
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Conjugation:
Non-conjugated
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Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
|---|---|---|
| Dilution Ratio | 1:100-200 | 1:100-250 |
Product Details
SYT4 Antibody (YA8407) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to SYT4.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman, Mouse, Rat
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Calculated Molecular Weight Predicted band size: 47.8 kDa
Full length human recombinant protein of human SYT4 produced in HEK293T cell.
Endogenous
Affinity purified
Non-conjugated
Unmodified
IgG1
Product Properties
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Appearance
Liquid
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Formulation
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
SYT4 is a Synaptotagmin family member which does not bind Ca(2+). Involved in neuronal dense core vesicles (DCVs) mobility through its interaction with KIF1A. Upon increased neuronal activity, phosphorylation by MAPK8/JNK1 destabilizes the interaction with KIF1A and captures DCVs to synapses. Plays a role in dendrite formation by melanocytes[1].
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Subcellular Localization
Cytoplasmic vesicle, secretory vesicle, neuronal dense core vesicle membrane
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Expression
Tissue_Specificity: Expressed in melanocytes (PubMed:23999003). Expressed in brain. Within brain, expression is highest in hippocampus, with substantial levels also detected in amygdala and thalamus (PubMed:23999003) -
Isoforms & Post-Translational Modification
Q9H2B2 has two isomers: Q9H2B2-1: 47958 Da (predicted); Q9H2B2-2: 46064 Da (predicted).
Phosphorylation at Ser-135 by MAPK8/JNK1 reduces interaction with KIF1A and neuronal dense core vesicles mobility -
Subunit
Interacts with KIF1A; the interaction increases in presence of calcium and decreases when SYT4 is phosphorylated at Ser-135
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SwissProt ID
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Synonyms
HsT1192
Documentation
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