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Cat. No.: HY-P85969

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TGF beta Receptor II Antibody (YA5661)

TGF beta Receptor II Antibody (YA5661) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to TGF beta Receptor II.

For research use only. We do not sell to patients.

Host:
Mouse
Isotype:
IgG1
Application:
IHC-P, WB, ICC/IF, ELISA
Reactivity :
Human

Formulation:
Supplied in PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

Conjugation:
Non-conjugated

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Applications
Product Details
Product Properties
- Appearance
- Formulation
- Storage & Stability
- Shipping
Background
Documentation
Help & FAQs
Classifications
Bioz

Applications

Application	IHC-P IHC-P: Immunohistochemistry-Paraffin	WB WB: Western Blot	ICC/IF ICC/IF: Immunocytochemistry/ Immunofluorescence	ELISA ELISA: Enzyme Linked Immunosorbent Assay
Dilution Ratio	1:100-500	1:500-2000	1:100-500	1:1000-5000

Product Details

Description

TGF beta Receptor II Antibody (YA5661) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to TGF beta Receptor II.

Host Mouse
Clonality Monoclonal
Species Reactivity
Human
Observed Molecular Weight

Observed band size: 80 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
Calculated Molecular Weight Predicted band size: 64 kDa

Immunogen

Synthesized peptide derived from human TGF β Receptor II AA range: 100-200

Purification

Protein G

Conjugation

Non-conjugated

Modification

Unmodified

Isotype

IgG1

Product Properties

Appearance

Liquid
Formulation

Supplied in PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping

Shipping with blue ice.

Background

Function

TGF beta Receptor II is a Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and thus regulates a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and activation of TGFBR1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways; Has transforming growth factor beta-activated receptor activity; Has transforming growth factor beta-activated receptor activity; Binds TGFB1, TGFB2 and TGFB3 in the picomolar affinity range without the participation of additional receptors. Blocks activation of SMAD2 and SMAD3 by TGFB1
Subcellular Localization

Cell membrane; Single-pass type I membrane protein; Membrane raft; Secreted
Isoforms & Post-Translational Modification

P37173 has 3 isomers: P37173-1: 64568 Da (predicted); P37173-2: 67457 Da (predicted); P37173-3: 9162 Da (predicted).
Phosphorylated on a Ser/Thr residue in the cytoplasmic domain
Subunit

Homodimer. Heterohexamer; TGFB1, TGFB2 and TGFB3 homodimeric ligands assemble a functional receptor composed of two TGFBR1 and TGFBR2 heterodimers to form a ligand-receptor heterohexamer. The respective affinity of TGFRB1 and TGFRB2 for the ligands may modulate the kinetics of assembly of the receptor and may explain the different biological activities of TGFB1, TGFB2 and TGFB3. Component of a complex composed of TSC22D1 (via N-terminus), TGFBR1 and TGFBR2; the interaction between TSC22D1 and TGFBR1 is inhibited by SMAD7 and promoted by TGFB1 (PubMed:21791611). Interacts with DAXX. Interacts with DYNLT4. Interacts with ZFYVE9; ZFYVE9 recruits SMAD2 and SMAD3 to the TGF-beta receptor. Interacts with and is activated by SCUBE3; this interaction does not affect TGFB1-binding to TGFBR2. Interacts with VPS39; this interaction is independent of the receptor kinase activity and of the presence of TGF-beta. Interacts with CLU (PubMed:8555189)
SwissProt ID

P37173
Gene ID

7048 [NCBI]