TTF-1 Antibody (YA2297)(PBS only)

Cat. No.: HY-P82552A: Data Sheet User Guide for Antibodies
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TTF-1 Antibody (YA2297) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to TTF-1.

For research use only. We do not sell to patients.

Size		Stock
50 μL		Get quote
100 μL		Get quote

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Documentation

Description

TTF-1 Antibody (YA2297) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to TTF-1.

Host

Rabbit

Molecular Weight

Predicted band size: 39 kDa;

Observed band size: 39 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.

Species Reactivity

Human, Hamster

SwissProt ID

P43699

Gene ID

7080 [NCBI]

Immunogen

A synthetic peptide of human TTF1

Application &
Dilution Ratio

Application	Dilution Ratio
WB WB: Western Blot	1:500-1:1000
ICC/IF ICC/IF: Immunocytochemistry/Immunofluorescence	1:50-1:200

Purity	Affinity Purified	Conjugation	Non-conjugated
Isotype	IgG

Appearance

Liquid

Formulation

Supplied in PBS, pH 7.4.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Background

Function：Transcription factor that binds and activates the promoter of thyroid specific genes such as thyroglobulin, thyroperoxidase, and thyrotropin receptor. Crucial in the maintenance of the thyroid differentiation phenotype. May play a role in lung development and surfactant homeostasis. Forms a regulatory loop with GRHL2 that coordinates lung epithelial cell morphogenesis and differentiation. Activates the transcription of GNRHR and plays a role in enhancing the circadian oscillation of its gene expression. Represses the transcription of the circadian transcriptional repressor NR1D1 (By similarity)

Subcellular Localization：Nucleus

Expression：
Tissue_specificity:thyroid and lungs

Isoforms & Post-Translational Modification：P43699 has 2 isomers: P43699-1: 38596 Da (predicted); P43699-3: 41737 Da (predicted).
Phosphorylated on serine residues by STK3/MST2

Subunit：Interacts with WWTR1

Research Field

Epigenetics and Nuclear Signaling

Synonyms

NKX2-1; NKX2A; TITF1; TTF1; Homeobox protein Nkx-2.1; Homeobox protein NK-2 homolog A; Thyroid nuclear factor 1; Thyroid transcription factor 1; TTF-1

Documentation

User Guide for Antibodies (1077 KB)