VAPA Antibody (YA6914)
(Synonyms: 33 kDa Vamp-associated protein antibody)VAPA Antibody (YA6914) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to VAPA.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, ICC/IF, IHC-P
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
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Conjugation:
Non-conjugated
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Applications
| Application |
WB
WB: Western Blot
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|---|---|
| Dilution Ratio | 1:1000 | 1:100 | 1:200 |
Product Details
VAPA Antibody (YA6914) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to VAPA.
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Host Rabbit
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Clonality Recombinant,Monoclonal
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Species ReactivityHuman, Mouse, Rat
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Observed Molecular WeightObserved band size: 28 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size：28 kDa
Recombinant protein within Human VAPA aa 1-100 / 249.
affinity purified.
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Liquid
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Formulation
Supplied in 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
VAPA is an Endoplasmic reticulum (ER)-anchored protein that mediates the formation of contact sites between the ER and endosomes via interaction with FFAT motif-containing proteins such as STARD3 or WDR44. STARD3-VAPA interaction enables cholesterol transfer from the ER to endosomes. Via interaction with WDR44 participates in neosynthesized protein export. In addition, recruited to the plasma membrane through OSBPL3 binding. The OSBPL3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface. With OSBPL3, may regulate ER morphology. May play a role in vesicle trafficking[1][2][3][4][5][6].
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Subcellular Localization
Endoplasmic reticulum membrane,Cell membrane,Cell junction, tight junction,Nucleus membrane
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Expression
Tissue_Specificity: Ubiquitous -
Isoforms & Post-Translational Modification
Q9P0L0 has two isomers: Q9P0L0-1: 27893 Da (predicted); Q9P0L0-2: 32614 Da (predicted).
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Subunit
Homodimer; disulfide-linked (PubMed:11511104, PubMed:33124732)
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SwissProt ID
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Synonyms
33 kDa Vamp-associated protein antibody
Documentation
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