YB-1 Antibody (YA7571)
(Synonyms: NSEP1, YB1, YBX1, Y-box-binding protein 1, YB-1, CCAAT-binding transcription factor I subunit A, DNA-binding protein B, Enhancer factor I subunit A, Nuclease-sensitive element-binding protein 1, Y-box transcription factor, CBF-A, DBPB, EFI-A)YB-1 Antibody (YA7571) is a Rabbit-derived and non-conjugated IgG, Kappa monoclonal antibody, targeting to YB-1.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IHC-P, ICC/IF, IP, ELISA
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in PBS (pH7.4) containing 50% glycerol, 0.05% Proclin 300, 0.05%BSA
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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WB
WB: Western Blot
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
ELISA
ELISA: Enzyme Linked Immunosorbent Assay
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IP
IP: Immunoprecipitation
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|---|---|---|---|---|---|
| Dilution Ratio | 1:200-1:1000 | 1:2000-1:10000 | 1:200-1:1000 | 1:5000-1:20000 | 1:50-1:200 |
Product Details
YB-1 Antibody (YA7571) is a Rabbit-derived and non-conjugated IgG, Kappa monoclonal antibody, targeting to YB-1.
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Host Rabbit
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Clonality Monoclonal,Recombinant
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Species ReactivityHuman, Mouse, Rat
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Observed Molecular WeightObserved band size: 49 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 36 kDa
The exact sequence is proprietary to MCE.
Endogenous
Protein A affinity purified
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS (pH7.4) containing 50% glycerol, 0.05% Proclin 300, 0.05%BSA
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
YB-1 (Y box binding protein 1) is a multifunctional transcription and translation factor, and is over-expressed in various human cancers. YB-1 is a 36 kDa protein, and consists of three domains: the alanine/proline-rich N-terminal domain (A/P domain), the cold shock domain (CSD), and the large C terminal domain (CTD) with alternating clusters of positively and negatively charged amino acid residues. YB-1 regulates cancer cell proliferation and progression, cell survival, cell proliferation and differentiation, stress response, and malignant cell transformation. YB-1 also participates in a wide variety of DNA/RNA-dependent events, including DNA reparation, pre-mRNA transcription and splicing, mRNA packaging, and regulation of mRNA stability and translation[1][2].
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Subcellular Localization
Cytoplasm,Nucleus,Cytoplasmic granule,Secreted,Secreted, extracellular exosome,Cytoplasm, P-body
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Isoforms & Post-Translational Modification
P67809: 324 amino acids, molecular weight 35924 Da.
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Subunit
Homodimer in the presence of ATP (PubMed:10817758, PubMed:11851341)
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SwissProt ID
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Synonyms
NSEP1, YB1, YBX1, Y-box-binding protein 1, YB-1, CCAAT-binding transcription factor I subunit A, DNA-binding protein B, Enhancer factor I subunit A, Nuclease-sensitive element-binding protein 1, Y-box transcription factor, CBF-A, DBPB, EFI-A
Documentation
References
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