Antiproliferative agent-15

Name: Antiproliferative agent-15
Brand: MedChemExpress
SKU: HY-W278944
Rating: 4.5 (0 reviews)

Cat. No.: HY-W278944 Purity: 99.18%: Data Sheet
COA

SDS
Handling Instructions
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Antiproliferative agent-15 is an thienopyrimidine derivated anticancer agent. Antiproliferative agent-15 shows antiproliferative activity against human colon (HCT116 and HCT15) and brain (LN-229 and GBM-10) cancer cell lines.

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Antiproliferative agent-15 화학구조

CAS No. : 19819-18-2

사이즈	재고	수량
1 mg	해외재고보유	Estimated Time of Arrival: December 31
5 mg	해외재고보유	Estimated Time of Arrival: December 31
10 mg	해외재고보유	Estimated Time of Arrival: December 31
25 mg	해외재고보유	Estimated Time of Arrival: December 31
50 mg	해외재고보유	Estimated Time of Arrival: December 31
100 mg	해외재고보유	Estimated Time of Arrival: December 31
200 mg	견적 받기
500 mg	견적 받기

or 대량구매 문의

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

This product is a controlled substance and not for sale in your territory.

고객리뷰

Based on 1 Customer Validation

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Biological Activity
순도&문서
References
고객리뷰

제품 설명

Cellular Effect

Cell Line	Type	Value	Description	References
A2780	IC₅₀	> 100 μM Compound: 6a	Antiproliferative activity against human A2780 cells after 72 hrs by MTT assay Antiproliferative activity against human A2780 cells after 72 hrs by MTT assay	[PMID: 28759878]
CHO	IC₅₀	> 100 μM Compound: 6a	Cytotoxicity against CHO cells assessed as reduction in cell survival after 72 hrs by MTT assay Cytotoxicity against CHO cells assessed as reduction in cell survival after 72 hrs by MTT assay	[PMID: 28759878]
HCT-116	IC₅₀	8.3 μM Compound: 6a	Antiproliferative activity against human HCT116 cells after 72 hrs by MTT assay Antiproliferative activity against human HCT116 cells after 72 hrs by MTT assay	[PMID: 28759878]
HCT-116	IC₅₀	> 10 μM Compound: 4e	Antiproliferative activity against human HCT116 cells assessed as reduction in cell viability measured after 24 to 48 hrs by MTT assay Antiproliferative activity against human HCT116 cells assessed as reduction in cell viability measured after 24 to 48 hrs by MTT assay	[PMID: 32153186]
HCT-15	IC₅₀	4.8 μM Compound: 6a	Antiproliferative activity against human HCT15 cells after 72 hrs by MTT assay Antiproliferative activity against human HCT15 cells after 72 hrs by MTT assay	[PMID: 28759878]
LN-229	IC₅₀	18.3 μM Compound: 6a	Antiproliferative activity against human LN229 cells after 72 hrs by MTT assay Antiproliferative activity against human LN229 cells after 72 hrs by MTT assay	[PMID: 28759878]
MCF7	IC₅₀	> 30 μM Compound: 6c	Antiproliferative activity against human MCF7 cells after 24 hrs by MTT assay Antiproliferative activity against human MCF7 cells after 24 hrs by MTT assay	[PMID: 29172540]
MDA-MB-231	IC₅₀	> 30 μM Compound: 6c	Antiproliferative activity against human MDA-MB-231 cells after 24 hrs by MTT assay Antiproliferative activity against human MDA-MB-231 cells after 24 hrs by MTT assay	[PMID: 29172540]

In Vitro

Antiproliferative agent-15 (compound 6a) shows antiproliferative activity against human colon (HCT116 and HCT15), brain (LN-229 and GBM-10) cancer cell lines, with IC50 values of 8.3 μM, 4.8 μM, 18.3 μM, and 12 μM, respectively. However, Antiproliferative agent-15 has no active against ovarian (A2780) cancer cell lines and normal cell line (CHO)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

분자량

282.37

화학식

C₁₆H₁₄N₂OS

CAS No.

19819-18-2

Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C1C(C(CCCC2)=C2S3)=C3N=C(C4=CC=CC=C4)N1

선적

Room temperature in continental US; may vary elsewhere.

보관

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

용액&용해도

In Vitro:

DMSO : 1.67 mg/mL (5.91 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.5415 mL	17.7074 mL	35.4148 mL
5 mM	0.7083 mL	3.5415 mL	7.0830 mL
10 mM	---	---	---

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Calculation results:

Working solution concentration: mg/mL

순도&문서

Purity: 99.18%

Select Batch:

Data Sheet (273 KB) SDS (393 KB)

COA (253 KB) HNMR (259 KB) RP-HPLC (229 KB) LCMS (95 KB)

Handling Instructions (2659 KB)

References

[1]. Haneen Amawi, et al. Thienopyrimidine derivatives exert their anticancer efficacy via apoptosis induction, oxidative stress and mitotic catastrophe. Eur J Med Chem. 2017 Sep 29;138:1053-1065. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.5415 mL	17.7074 mL	35.4148 mL	88.5369 mL
DMSO	5 mM	0.7083 mL	3.5415 mL	7.0830 mL	17.7074 mL