2. Vitamin D Related/Nuclear Receptor
  3. Androgen Receptor
  4. AR/AR-V7-IN-1

AR/AR-V7-IN-1 (Compound 20i) is an AR/ARV7 inhibitor (IC50 = 172.85 nM). AR/AR-V7-IN-1 potently inhibits cell growth with IC50 values of 4.87 and 2.07 μM in the LNCaP and 22RV1 cell lines, respectively. AR/AR-V7-IN-1 exhibits effective tumor growth inhibition in the 22RV1 xenograft study. AR/AR-V7-IN-1 can be used for the research of prostate cancer.

Para uso exclusivo en investigación. No vendemos a pacientes.

AR/AR-V7-IN-1

AR/AR-V7-IN-1 Estructura química

No. CAS : 2964558-54-9

Tamaño Precio Stock Cantidad
5 mg Obtener un presupuesto 11 - 13 weeks 10 - 12 weeks 12 - 14 weeks 11 - 13 weeks
10 mg Obtener un presupuesto 11 - 13 weeks 10 - 12 weeks 12 - 14 weeks 11 - 13 weeks
25 mg Obtener un presupuesto 11 - 13 weeks 10 - 12 weeks 12 - 14 weeks 11 - 13 weeks
50 mg   Obtener un presupuesto  
100 mg   Obtener un presupuesto  
Synthetic products have potential research and development risk.

* Seleccione Cantidad antes de agregar artículos.

This product is a controlled substance and not for sale in your territory.

Revisión del cliente

Based on 1 Customer Validation

AR/AR-V7-IN-1 Related Antibodies

Top Publications Citing Use of Products

  • Actividad biológica

  • Pureza y Documentación

  • Referencias

  • Revisión del cliente

Descripciòn

AR/AR-V7-IN-1 (Compound 20i) is an AR/ARV7 inhibitor (IC50 = 172.85 nM). AR/AR-V7-IN-1 potently inhibits cell growth with IC50 values of 4.87 and 2.07 μM in the LNCaP and 22RV1 cell lines, respectively. AR/AR-V7-IN-1 exhibits effective tumor growth inhibition in the 22RV1 xenograft study. AR/AR-V7-IN-1 can be used for the research of prostate cancer[1].

Cellular Effect
Cell Line Type Value Description References
CWR22R IC50
4.87 μM
Compound: 20i
Antiproliferative activity against human 22Rv1 cells assessed as reduction in cell viability incubated for 24 hrs by CCK8 assay
Antiproliferative activity against human 22Rv1 cells assessed as reduction in cell viability incubated for 24 hrs by CCK8 assay
[PMID: 38626524]
HEK293 IC50
1.98 μM
Compound: 20i
Antiproliferative activity against HEK293 cells transfected with androgen receptor splice variant 7 assessed as inhibition of cell growth
Antiproliferative activity against HEK293 cells transfected with androgen receptor splice variant 7 assessed as inhibition of cell growth
[PMID: 38626524]
LNCaP IC50
2.07 μM
Compound: 20i
Antiproliferative activity against human LNCaP cells assessed as reduction in cell viability incubated for 24 hrs by CCK8 assay
Antiproliferative activity against human LNCaP cells assessed as reduction in cell viability incubated for 24 hrs by CCK8 assay
[PMID: 38626524]
Peso molecular

660.22

Fòrmula

C36H43ClFN7O2
No. CAS
SMILES

FCCCN(C1)CC1NC2=CC=C(C=C2)CC3CCN(C4=CC=C(N=N4)C(N[C@@H]5CC[C@H](CC5)OC6=CC(Cl)=C(C=C6)C#N)=O)CC3
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

AR/AR-V7-IN-1 Related Classifications

  • Calculadora de molaridad

  • Calculadora de dilución

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AR/AR-V7-IN-12964558-54-9Androgen ReceptorLNCaP22RV1prostate cancerInhibitorinhibitorinhibit

Productos vistos recientemente:

Consulta en línea

Your information is safe with us. * Required Fields.

Nombre del producto

  

Requested Quantity *

Nombre del solicitante *

 

Saludo

Direcciòn del E-mail *

 

Número de teléfono *

Department

 

Nombre de la Organizaciòn *

City

Provincia

Country or Region *

      

Observaciones

Consulta para venta a granel

Inquiry Information

Nombre del producto:
AR/AR-V7-IN-1
Cat. No.:
HY-163510
Cantidad:
MCE Japan Authorized Agent:

Revisión del cliente

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Nombre del producto

  

Lot #

Nombre del solicitante *

 

Direcciòn del E-mail *

Número de teléfono

 

Department *

Nombre de la Organizaciòn *

 

Country or Region *

Observaciones

SAFETY DATA SHEET (SDS)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.