2964558-54-9
2964558-54-9
Chemical Structure
AR/AR-V7-IN-1
- CAS No.: 2964558-54-9
- Formula:C36H43ClFN7O2
- Molecular Weight:660.22
InChIKey: YYSOVURNYFNXBO-OZIXAUCHSA-N
SMILES: FCCCN(C1)CC1NC2=CC=C(C=C2)CC3CCN(C4=CC=C(N=N4)C(N[C@@H]5CC[C@H](CC5)OC6=CC(Cl)=C(C=C6)C#N)=O)CC3
Biological Activity: AR/AR-V7-IN-1 (Compound 20i) is an AR/ARV7 inhibitor (IC50 = 172.85 nM). AR/AR-V7-IN-1 potently inhibits cell growth with IC50 values of 4.87 and 2.07 μM in the LNCaP and 22RV1 cell lines, respectively. AR/AR-V7-IN-1 exhibits effective tumor growth inhibition in the 22RV1 xenograft study. AR/AR-V7-IN-1 can be used for the research of prostate cancer[1].
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AR/AR-V7-IN-1 | AR/AR-V7-IN-1 (Compound 20i) is an AR/ARV7 inhibitor (IC50 = 172.85 nM). AR/AR-V7-IN-1 potently inhibits cell growth with IC50 values of 4.87 and 2.07 μM in the LNCaP and 22RV1 cell lines, respectively. AR/AR-V7-IN-1 exhibits effective tumor growth inhibition in the 22RV1 xenograft study. AR/AR-V7-IN-1 can be used for the research of prostate cancer. | |||||||||||||||||||||
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