2. Vitamin D Related/Nuclear Receptor
  3. Androgen Receptor
  4. AR/AR-V7-IN-1

AR/AR-V7-IN-1 (Compound 20i) is an AR/ARV7 inhibitor (IC50 = 172.85 nM). AR/AR-V7-IN-1 potently inhibits cell growth with IC50 values of 4.87 and 2.07 μM in the LNCaP and 22RV1 cell lines, respectively. AR/AR-V7-IN-1 exhibits effective tumor growth inhibition in the 22RV1 xenograft study. AR/AR-V7-IN-1 can be used for the research of prostate cancer.

For research use only. We do not sell to patients.

AR/AR-V7-IN-1

AR/AR-V7-IN-1 Chemical Structure

CAS No. : 2964558-54-9

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AR/AR-V7-IN-1 Related Antibodies

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Description

AR/AR-V7-IN-1 (Compound 20i) is an AR/ARV7 inhibitor (IC50 = 172.85 nM). AR/AR-V7-IN-1 potently inhibits cell growth with IC50 values of 4.87 and 2.07 μM in the LNCaP and 22RV1 cell lines, respectively. AR/AR-V7-IN-1 exhibits effective tumor growth inhibition in the 22RV1 xenograft study. AR/AR-V7-IN-1 can be used for the research of prostate cancer[1].

Cellular Effect
Cell Line Type Value Description References
CWR22R IC50
4.87 3
Compound: 20i
Antiproliferative activity against human 22Rv1 cells assessed as reduction in cell viability incubated for 24 hrs by CCK8 assay
Antiproliferative activity against human 22Rv1 cells assessed as reduction in cell viability incubated for 24 hrs by CCK8 assay
[PMID: 38626524]
HEK293 IC50
1.98 3
Compound: 20i
Antiproliferative activity against HEK293 cells transfected with androgen receptor splice variant 7 assessed as inhibition of cell growth
Antiproliferative activity against HEK293 cells transfected with androgen receptor splice variant 7 assessed as inhibition of cell growth
[PMID: 38626524]
LNCaP IC50
2.07 3
Compound: 20i
Antiproliferative activity against human LNCaP cells assessed as reduction in cell viability incubated for 24 hrs by CCK8 assay
Antiproliferative activity against human LNCaP cells assessed as reduction in cell viability incubated for 24 hrs by CCK8 assay
[PMID: 38626524]
Molecular Weight

660.22

Formula

C36H43ClFN7O2
CAS No.
SMILES

FCCCN(C1)CC1NC2=CC=C(C=C2)CC3CCN(C4=CC=C(N=N4)C(N[C@@H]5CC[C@H](CC5)OC6=CC(Cl)=C(C=C6)C#N)=O)CC3
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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AR/AR-V7-IN-1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AR/AR-V7-IN-12964558-54-9Androgen ReceptorLNCaP22RV1prostate cancerInhibitorinhibitorinhibit

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