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Cat. No.: HY-163510

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AR/AR-V7-IN-1

AR/AR-V7-IN-1 (Compound 20i) is an AR/ARV7 inhibitor (IC₅₀ = 172.85 nM). AR/AR-V7-IN-1 potently inhibits cell growth with IC₅₀ values of 4.87 and 2.07 μM in the LNCaP and 22RV1 cell lines, respectively. AR/AR-V7-IN-1 exhibits effective tumor growth inhibition in the 22RV1 xenograft study. AR/AR-V7-IN-1 can be used for the research of prostate cancer.

For research use only. We do not sell to patients.

CAS No.: 2964558-54-9
Formula: C₃₆H₄₃ClFN₇O₂
Molecular Weight:660.22

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (262 KB)

AR/AR-V7-IN-1 Chemical Structure

CAS No.: 2964558-54-9

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
CWR22R	IC₅₀	4.87 μM Compound: 20i	Antiproliferative activity against human 22Rv1 cells assessed as reduction in cell viability incubated for 24 hrs by CCK8 assay Antiproliferative activity against human 22Rv1 cells assessed as reduction in cell viability incubated for 24 hrs by CCK8 assay	[PMID: 38626524]
HEK293	IC₅₀	1.98 μM Compound: 20i	Antiproliferative activity against HEK293 cells transfected with androgen receptor splice variant 7 assessed as inhibition of cell growth Antiproliferative activity against HEK293 cells transfected with androgen receptor splice variant 7 assessed as inhibition of cell growth	[PMID: 38626524]
LNCaP	IC₅₀	2.07 μM Compound: 20i	Antiproliferative activity against human LNCaP cells assessed as reduction in cell viability incubated for 24 hrs by CCK8 assay Antiproliferative activity against human LNCaP cells assessed as reduction in cell viability incubated for 24 hrs by CCK8 assay	[PMID: 38626524]

Chemical Information

CAS No. 2964558-54-9
Molecular Weight 660.22
Formula C₃₆H₄₃ClFN₇O₂
SMILES

FCCCN(C1)CC1NC2=CC=C(C=C2)CC3CCN(C4=CC=C(N=N4)C(N[C@@H]5CC[C@H](CC5)OC6=CC(Cl)=C(C=C6)C#N)=O)CC3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (262 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Yang Y, et al. Novel selective agents for the degradation of AR/AR-V7 to treat advanced prostate cancer. Eur J Med Chem. 2024 Apr 15;271:116400. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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